Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase
about
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type proteinCoordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of FhitNitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegansThe hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate bindingAdenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substratesHint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferasesMolecular mechanism of DNA deadenylation by the neurological disease protein aprataxinFeminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimerDi-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacementControl of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae.Common fragile sites: genomic hotspots of DNA damage and carcinogenesisRole of genetics in the diagnosis and prognosis of Crohn's diseaseHigh-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolutionGift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of ActionCrystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteinsThe Saccharomyces cerevisiae YOR163w gene encodes a diadenosine 5', 5"'-P1,P6-hexaphosphate (Ap6A) hydrolase member of the MutT motif (Nudix hydrolase) family.Control of 5',5'-dinucleoside triphosphate catabolism by APH1, a Saccharomyces cerevisiae analog of human FHITImpaired FHIT expression characterizes serous ovarian carcinomaThe histidine triad protein Hint is not required for murine development or Cdk7 functionIsolation, cloning and characterization of a low-molecular-mass purine nucleoside- and nucleotide-binding proteinActivation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Reduced FHIT expression is associated with mismatch repair deficient and high CpG island methylator phenotype colorectal cancer.Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase CβAssociation of allelic loss at the FHIT locus and p53 alterations with tumour kinetics and chromosomal instability in non-small cell lung carcinomas (NSCLCs).The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow.Cloning and expression of a new cDNA from monocotyledonous plants coding for a diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase from barley (Hordeum vulgare).High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesisIdentification of diadenosine triphosphate in Brugia malayi by reverse phase high performance liquid chromatography and MALDI mass spectrometry.Crystallization and preliminary X-ray analysis of the diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase from Mycobacterium tuberculosis H37RvReplacement of Fhit in cancer cells suppresses tumorigenicityThe histidine triad superfamily of nucleotide-binding proteins.Replicative Stress and the FHIT Gene: Roles in Tumor Suppression, Genome Stability and Prevention of Carcinogenesis.Ap4A induces apoptosis in human cultured cells.Brewers' rice induces apoptosis in azoxymethane-induced colon carcinogenesis in rats via suppression of cell proliferation and the Wnt signaling pathwayMolecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids.Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell proliferation and apoptosis.
P2860
Q22010421-17A92B30-3AD4-4D90-9A0F-690B10B5E5CBQ24309646-0ECD93C6-C03A-4AA1-8E06-078E3D3B8E7DQ24313542-D1851D20-46E4-49A0-ADFF-F819F2D21E29Q24317206-F3ABC919-A6CD-44D8-8013-8B5D97E6B915Q24320007-EB5CF05A-351A-45CC-9D5D-923C5ACE2AB0Q24532208-E9F344EC-1EA4-4624-976E-37A46BD131BAQ24550737-5E7DA83D-97B8-42B7-BEB8-1144A7390453Q24642988-E2377D4D-FE02-4F50-BD69-C90172AE2EAEQ24643024-FA250567-2797-4287-9A51-1ACAB4C28FC8Q24649493-6465B5B1-1341-4812-9C2F-518070C58DAAQ24651265-96C4ADFC-8C00-49C1-9216-7A5F61CFD469Q24791300-6D5F8D31-B6A9-4F24-AA77-B6E402AE3D26Q24794183-D8F80190-5217-4CB1-B3DF-0F9AD91F175DQ24794916-E3B4F23B-065A-49EA-8153-4AD7C5F5880BQ26825040-894FC815-A505-42A0-82FA-30F0F119E67AQ27003222-F11A8BBF-6A41-4E28-AAA1-0C833E7388E9Q27670520-1F15BB53-F029-4A9D-8717-7FA7ECA84A81Q27702304-6FBB1ABF-0297-4F3A-B4B1-7E29C074C38CQ27738382-1DA19093-9A05-4B38-917E-10050697A7CCQ27934558-1F9DFE3E-41F9-495B-B5A0-6A9F209DA034Q27935586-80BF0679-5EB2-4E54-AF58-5118833E711CQ28344344-E2D7B69C-98AA-4921-B13D-6AC4D895F765Q28510492-9130CDDF-E115-4F04-91F9-107697925221Q28571078-6E9DFD04-9C99-411D-AEB8-0EF7F0652A36Q30543570-81322E51-06FF-455D-8149-C2972A0FA0A5Q30543686-A52953C7-3FFC-4568-8245-4241C0C3C941Q30670527-FFE958F3-0BAB-4119-A34D-63E29BAD86CAQ31909986-9674B2FD-222B-4835-A281-00B790B8E89FQ31994723-0275D9CF-94DB-46E7-A9A4-A9EEEE26A915Q32035216-40945245-2E36-4333-8DEA-8430A868DFDAQ33274578-8043664B-A846-4098-8C6D-7FA82E5525FAQ33290858-96E3B92D-5D58-4C58-851A-B6C838A700E8Q33707292-AA44E9ED-B031-4CB7-A8EF-DAAA7A38230BQ33726007-09FD528E-EDBC-4C84-A393-078488773790Q33738439-FD1A7AA9-CFCA-4700-B88C-1D680E4FBC46Q33820327-56F307B8-EF90-43AB-9F5C-5E7D99824E4BQ33871428-002304DE-DE48-43F0-97DC-4D5FF8D3F198Q34100186-538C7EA2-73B1-44C0-A544-4ACC2D8822AFQ34198390-20ED5AAF-D77E-498F-B2ED-D2B42CD638D8Q34382649-75666779-20EF-4673-BD34-17B189EE1E12
P2860
Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@ast
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en-gb
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@nl
type
label
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@ast
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en-gb
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@nl
prefLabel
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@ast
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en-gb
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@nl
P2093
P921
P3181
P356
P1433
P1476
Fhit, a putative tumor suppres ...... '-P1,P3-triphosphate hydrolase
@en
P2093
A Guranowski
A K Robinson
L D Barnes
P N Garrison
S W Ingram
Z Siprashvili
P304
P3181
P356
10.1021/BI961415T
P407
P577
1996-09-10T00:00:00Z