Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
about
Aprataxin, causative gene product for EAOH/AOA1, repairs DNA single-strand breaks with damaged 3'-phosphate and 3'-phosphoglycolate endsAprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activitiesCoordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate bindingThe nitrilase superfamily: classification, structure and functionAdenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferasesDi-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the alpha-beta bridging oxygen and beta phosphorus replacementControl of dinucleoside polyphosphates by the FHIT-homologous HNT2 gene, adenine biosynthesis and heat shock in Saccharomyces cerevisiae.Single-molecule imaging analysis of Ras activation in living cells.Synthesis of two fluorescent GTPγS molecules and their biological relevanceFhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1PCR amplification and transcription for site-specific labeling of large RNA molecules by a two-unnatural-base-pair systemUnnatural base pair systems toward the expansion of the genetic alphabet in the central dogmaSpontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs.Disease-associated mutations inactivate AMP-lysine hydrolase activity of Aprataxin.Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors.Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.Phosphate-Modified Nucleotides for Monitoring Enzyme Activity.Activity-based probe for histidine kinase signaling.Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.Impact of FHIT loss on the translation of cancer-associated mRNAs.Exploring NMR methods as a tool to select suitable fluorescent nucleotide analogues.Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system.New interactions between tumor suppressor Fhit protein and a nonhydrolyzable analog of its AP4 A substrate.Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs.Recent progress in the study of the intracellular functions of diadenosine polyphosphatesSelective Monitoring of the Enzymatic Activity of the Tumor Suppressor Fhit
P2860
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P2860
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@ast
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@en
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@nl
type
label
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@ast
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@en
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@nl
prefLabel
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@ast
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@en
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@nl
P2093
P2860
P356
P1476
Fhit-nucleotide specificity probed with novel fluorescent and fluorogenic substrates
@en
P2093
A Draganescu
S C Hodawadekar
P2860
P304
P356
10.1074/JBC.275.7.4555
P407
P577
2000-02-18T00:00:00Z