Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
about
Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activityInteraction of the Grb7 adapter protein with Rnd1, a new member of the Rho familyThe EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent mannerMetalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingEphB1 associates with Grb7 and regulates cell migrationEph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responsesNck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinaseJuxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cellsInteractions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred.Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activationGrb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesisDiacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domainsLiprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylationSAM as a protein interaction domain involved in developmental regulationPDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptorThe Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptorIdentification and phylogenetic analysis of Dictyostelium discoideum kinesin proteins.Solution structure of the receptor tyrosine kinase EphB2 SAM domain and identification of two distinct homotypic interaction sitesMonomeric structure of the human EphB2 sterile alpha motif domainStructural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificityStructure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAMGrb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferationAssociation of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partnerIdentification of Grb10 as a direct substrate for members of the Src tyrosine kinase familyLocalization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 poolReplacing two conserved tyrosines of the EphB2 receptor with glutamic acid prevents binding of SH2 domains without abrogating kinase activity and biological responsesEvidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functionsSignals from Eph and ephrin proteins: a developmental tool kitMultiple signaling interactions of Abl and Arg kinases with the EphB2 receptorCharacterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissuesManipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activityCloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gammaInteraction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesA novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1AmGrb10 interacts with Nedd4Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissuesAdaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction.Inhibition of hGrb10 binding to the insulin receptor by functional domain-mediated oligomerization.
P2860
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P2860
Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells
description
1996 nî lūn-bûn
@nan
1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Ligand activation of ELK recep ...... in vascular endothelial cells
@ast
Ligand activation of ELK recep ...... in vascular endothelial cells
@en
Ligand activation of ELK recep ...... in vascular endothelial cells
@en-gb
Ligand activation of ELK recep ...... in vascular endothelial cells
@nl
type
label
Ligand activation of ELK recep ...... in vascular endothelial cells
@ast
Ligand activation of ELK recep ...... in vascular endothelial cells
@en
Ligand activation of ELK recep ...... in vascular endothelial cells
@en-gb
Ligand activation of ELK recep ...... in vascular endothelial cells
@nl
prefLabel
Ligand activation of ELK recep ...... in vascular endothelial cells
@ast
Ligand activation of ELK recep ...... in vascular endothelial cells
@en
Ligand activation of ELK recep ...... in vascular endothelial cells
@en-gb
Ligand activation of ELK recep ...... in vascular endothelial cells
@nl
P2093
P2860
P356
P1476
Ligand activation of ELK recep ...... in vascular endothelial cells
@en
P2093
P2860
P304
P356
10.1074/JBC.271.38.23588
P407
P577
1996-09-20T00:00:00Z