SUMO modification of Huntingtin and Huntington's disease pathology
about
Persistence of morning anticipation behavior and high amplitude morning startle response following functional loss of small ventral lateral neurons in DrosophilaCUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasomeDevelopment and application of a DNA microarray-based yeast two-hybrid systemRhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityRegulation of cardiac specific nkx2.5 gene activity by small ubiquitin-like modifierHuntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicityPolyglutamine expansion of huntingtin impairs its nuclear exportHistone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modificationsDual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complexPalmitoylation of huntingtin by HIP14 is essential for its trafficking and functionSumoylation in Synaptic Function and DysfunctionThe many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapyIron dysregulation in Huntington's diseaseIntrabodies as neuroprotective therapeuticsComparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's diseaseThe N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceReinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes.Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegenerationHuntingtin's function in axonal transport is conserved in Drosophila melanogasterThe ankyrin repeat domain of Huntingtin interacting protein 14 contains a surface aromatic cage, a potential site for methyl-lysine bindingStructure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR ApproachSUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p.The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.Huntingtin functions as a scaffold for selective macroautophagyPredicting protein sumoylation sites from sequence featuresOpposing effects of polyglutamine expansion on native protein complexes contribute to SCA1Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility geneNormal huntingtin function: an alternative approach to Huntington's diseaseThe proteome response to amyloid protein expression in vivoSUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitroSUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cellsPias1 interaction and sumoylation of metabotropic glutamate receptor 8p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathSerine 421 regulates mutant huntingtin toxicity and clearance in mice.Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregationDisrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in miceBiophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.
P2860
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P2860
SUMO modification of Huntingtin and Huntington's disease pathology
description
2004 nî lūn-bûn
@nan
2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
SUMO modification of Huntingtin and Huntington's disease pathology
@ast
SUMO modification of Huntingtin and Huntington's disease pathology
@en
SUMO modification of Huntingtin and Huntington's disease pathology
@en-gb
SUMO modification of Huntingtin and Huntington's disease pathology
@nl
type
label
SUMO modification of Huntingtin and Huntington's disease pathology
@ast
SUMO modification of Huntingtin and Huntington's disease pathology
@en
SUMO modification of Huntingtin and Huntington's disease pathology
@en-gb
SUMO modification of Huntingtin and Huntington's disease pathology
@nl
prefLabel
SUMO modification of Huntingtin and Huntington's disease pathology
@ast
SUMO modification of Huntingtin and Huntington's disease pathology
@en
SUMO modification of Huntingtin and Huntington's disease pathology
@en-gb
SUMO modification of Huntingtin and Huntington's disease pathology
@nl
P2093
P921
P3181
P356
P1433
P1476
SUMO modification of Huntingtin and Huntington's disease pathology
@en
P2093
Erica Rockabrand
J Lawrence Marsh
Joan S Steffan
Judit Pallos
Katalin Illes
Leslie Michels Thompson
Lloyd C Trotman
Namita Agrawal
Natalia Slepko
Tamas Lukacsovich
P3181
P356
10.1126/SCIENCE.1092194
P407
P577
2004-04-02T00:00:00Z