Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
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Pharmacometabolomic signature of ataxia SCA1 mouse model and lithium effectsComparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxiaDevelopment and application of a DNA microarray-based yeast two-hybrid systemSuppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicityUbiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunctionmiR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesisAnimal models of polyglutamine diseases and therapeutic approachesPathogenic mechanisms of a polyglutamine-mediated neurodegenerative disease, spinocerebellar ataxia type 1Epigenetic principles and mechanisms underlying nervous system functions in health and diseaseGene, Stem Cell, and Alternative Therapies for SCA 1Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of diseaseCell biology of spinocerebellar ataxiaBeyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1The unstable repeats--three evolving faces of neurological diseasePolyglutamine neurodegeneration: expanded glutamines enhance native functionsLarge Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice.Triplet repeat-derived siRNAs enhance RNA-mediated toxicity in a Drosophila model for myotonic dystrophyStructural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and CapicuaProtein-protein interactions as a strategy towards protein-specific drug design: the example of ataxin-1Phosphorylation of S776 and 14-3-3 binding modulate ataxin-1 interaction with splicing factorsPartial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesisUbe2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIPProtein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy.Direct inhibition of Gcn5 protein catalytic activity by polyglutamine-expanded ataxin-7.Gcn5 loss-of-function accelerates cerebellar and retinal degeneration in a SCA7 mouse model.Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy.Trinucleotide repeats: a structural perspectiveSCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability.Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Glial cell lineage expression of mutant ataxin-1 and huntingtin induces developmental and late-onset neuronal pathologies in Drosophila modelsNucleocytoplasmic shuttling activity of ataxin-3.RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1High-resolution network biology: connecting sequence with function.Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay.Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice.Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties.
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P2860
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@ast
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@en
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@nl
type
label
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@ast
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@en
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@nl
prefLabel
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@ast
Opposing effects of polyglutam ...... n complexes contribute to SCA1
@en
Opposing effects of polyglutam ...... n complexes contribute to SCA1
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Opposing effects of polyglutam ...... n complexes contribute to SCA1
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David E Hill
Janghoo Lim
Juan Crespo-Barreto
Paymaan Jafar-Nejad
Ronald Richman
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P356
10.1038/NATURE06731
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P577
2008-04-10T00:00:00Z
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P6179
1004830363