Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias
about
Cartilage oligomeric matrix protein protects cells against death by elevating members of the IAP family of survival proteinsCartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritisInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinADAMTS-12 associates with and degrades cartilage oligomeric matrix proteinA mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasiaMultiple epiphyseal dysplasia mutations in MATN3 cause misfolding of the A-domain and prevent secretion of mutant matrilin-3Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation.Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMPCrystal structure of the N-terminal NC4 domain of collagen IX, a zinc binding member of the laminin-neurexin-sex hormone binding globulin (LNS) domain familyThe crystal structure of the signature domain of cartilage oligomeric matrix protein: implications for collagen, glycosaminoglycan and integrin bindingSkeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagenD469del-COMP retention in chondrocytes stimulates caspase-independent necroptosisCartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferationAntioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasiaModulation of Nr-13 antideath activity by peptide aptamers.Matrilin-1 is an inhibitor of neovascularization.Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth.Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage.Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage.Pseudoachondroplasia/COMP - translating from the bench to the bedside.ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinMatrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.Elevated Levels of Cartilage Oligomeric Matrix Protein during In Vitro Cartilage Matrix Generation Decrease Collagen Fibril Diameter.Mild myopathy is associated with COMP but not MATN3 mutations in mouse models of genetic skeletal diseases.Cartilage oligomeric matrix protein in idiopathic pulmonary fibrosis.Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasiaCartilage oligomeric matrix protein promotes cell attachment via two independent mechanisms involving CD47 and alphaVbeta3 integrin.NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H.The thrombospondins.Unique matrix structure in the rough endoplasmic reticulum cisternae of pseudoachondroplasia chondrocytes.Enhanced activity of transforming growth factor β1 (TGF-β1) bound to cartilage oligomeric matrix protein.Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand.A 3D Porous Gelatin-Alginate-Based-IPN Acts as an Efficient Promoter of Chondrogenesis from Human Adipose-Derived Stem Cells.Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma.A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritisCollagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure.Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-α treatment.The matrilins--adaptor proteins in the extracellular matrix.Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments.
P2860
Q24300020-78D423C1-C313-4697-AF31-D4E6507A53B9Q24307967-F0BC6A73-929E-4DAE-A164-8A5BB732BE54Q24313406-BB780EC1-3602-42EA-B62C-08B1C194B652Q24317122-9C5F7E0C-8FB9-4633-BF22-7739A9202011Q24642755-1251C1EE-65F4-464D-BA9F-1FBF2AA2E136Q24651381-584E84EC-2A58-459E-BEC1-5AB205116C40Q24653702-CD3F7199-CB7B-40F1-9C03-7B9667617CBFQ24653736-92D42E4B-1B2A-4CA5-89D9-716B8EB0C403Q27645307-25C1185B-CCDB-4C6A-B358-ADD11D308177Q27654058-D5B0F5ED-A037-4D3B-9946-92BEC22AB91EQ28508457-781089B8-FC1B-4FEC-A84A-41EABA200A05Q28569144-1C1044A7-DC59-4224-B1AC-F1A021ED1EA9Q28569341-8FE33B57-52AC-4DC4-B4CC-3A1D842AE32CQ28648075-C7C24256-FE31-40AA-BDB3-EFC5B681EF51Q33253911-E317A0A6-489F-476E-AA77-F73010D94B2AQ33619544-63AAFC24-8FBF-48CB-AE75-DF57226B0DFAQ33823788-ACFC1A07-29E2-43D6-A443-B472DB5658FDQ33892773-28AC1FCA-2070-48CD-8EC7-1C913CF9875BQ33964749-5EB6932C-80A3-4920-B1D0-CFFF22466D5FQ34407214-6993111F-4E11-4B1C-8CB3-D770A2A4CEE0Q34508676-3D673395-2378-4204-A368-FE27BEF6103FQ34683323-A5C5426B-349C-4F0B-A325-3837131640CBQ34977924-A96305E4-02AE-4080-BE48-41BA7B8C7EF3Q35060915-FE8FC75E-DA47-40C2-87D6-433A74A52900Q35077927-81A098FA-987F-4527-99F2-EFCD09580D3DQ35099438-B0C47D7C-8156-4302-AF72-0EB203AD8826Q35149818-AC08DA72-EE4F-4BF0-A2FE-F2B28A91A89CQ35150029-5103E024-3BCD-4DAD-A385-E8F23E550B46Q35230013-C527A9B6-5FEE-41D1-B262-992FC9918BD5Q35570417-4E9B6C60-872A-4CA2-8FEE-F81F25FC14A5Q35604546-320F89ED-00A4-43A1-BD7E-7BF527A3D7ECQ35637449-50013FA2-86D7-4FDD-B8FC-EEE67560678EQ35708512-FF9F0712-5118-42D7-97F0-D544E49EF9D3Q35864817-1609AAC9-017C-467C-824F-2B8D37828C64Q35873980-D950469D-9216-45E7-8325-E559FC5ED46CQ36075753-A50D973D-931C-4E16-A30F-98350BCEBAEDQ36080564-39E70F4D-0DCB-442A-B728-5DA35D3CF41EQ36084932-3EF960A3-060B-4B22-A2D7-CB5204C6771AQ36156037-45F5EED2-6787-4444-9901-E6001B7E6C1CQ36746008-0CC06DA9-5984-440A-AB9D-BF4EC5EC6525
P2860
Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Interactions between the carti ...... hogenesis of chondrodysplasias
@ast
Interactions between the carti ...... hogenesis of chondrodysplasias
@en
Interactions between the carti ...... hogenesis of chondrodysplasias
@en-gb
Interactions between the carti ...... hogenesis of chondrodysplasias
@nl
type
label
Interactions between the carti ...... hogenesis of chondrodysplasias
@ast
Interactions between the carti ...... hogenesis of chondrodysplasias
@en
Interactions between the carti ...... hogenesis of chondrodysplasias
@en-gb
Interactions between the carti ...... hogenesis of chondrodysplasias
@nl
prefLabel
Interactions between the carti ...... hogenesis of chondrodysplasias
@ast
Interactions between the carti ...... hogenesis of chondrodysplasias
@en
Interactions between the carti ...... hogenesis of chondrodysplasias
@en-gb
Interactions between the carti ...... hogenesis of chondrodysplasias
@nl
P2093
P921
P356
P1476
Interactions between the carti ...... hogenesis of chondrodysplasias
@en
P2093
Henning H Mann
Jürgen Engel
Mats Paulsson
Raimund Wagener
P304
25294-25298
P356
10.1074/JBC.M403778200
P407
P50
P577
2004-04-09T00:00:00Z