Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment
about
The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and compositionMHC class II presentation of gp100 epitopes in melanoma cells requires the function of conventional endosomes and is influenced by melanosomes.The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction.Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.Two SNPs in the SILV gene are associated with silver coat colour in ponies.Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle.Different approaches for assaying melanosome transferProprotein convertases process Pmel17 during secretion.Reduced glutathione disrupts the intracellular trafficking of tyrosinase and tyrosinase-related protein-1 but not dopachrome tautomerase and Pmel17 to melanosomes, which results in the attenuation of melanization.Dual loss of ER export and endocytic signals with altered melanosome morphology in the silver mutation of Pmel17Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules.SOX9 is a key player in ultraviolet B-induced melanocyte differentiation and pigmentationThe melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.[Biogenesis of melanosomes - the chessboard of pigmentation].The Silver locus product Pmel17/gp100/Silv/ME20: controversial in name and in function.Premelanosome amyloid-like fibrils are composed of only golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes.The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretaseComparison of bone morphogenetic protein-2 and osteoactivin for mesenchymal cell differentiation: effects of bolus and continuous administration.Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway.Genotype at the PMEL17 locus affects social and explorative behaviour in chickens.Pmel17: controversial indeed but critical to melanocyte function.Genotype on the pigmentation regulating PMEL17 gene affects behavior in chickens raised without physical contact with conspecifics.Biogenesis of MelanosomesReply to Valencia et al
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P2860
Epitope mapping of the melanosomal matrix protein gp100 (PMEL17): rapid processing in the endoplasmic reticulum and glycosylation in the early Golgi compartment
description
2004 nî lūn-bûn
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2004 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2004 թվականի հուլիսին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Epitope mapping of the melanos ...... in the early Golgi compartment
@ast
Epitope mapping of the melanos ...... in the early Golgi compartment
@en
Epitope mapping of the melanos ...... in the early Golgi compartment
@en-gb
Epitope mapping of the melanos ...... in the early Golgi compartment
@nl
type
label
Epitope mapping of the melanos ...... in the early Golgi compartment
@ast
Epitope mapping of the melanos ...... in the early Golgi compartment
@en
Epitope mapping of the melanos ...... in the early Golgi compartment
@en-gb
Epitope mapping of the melanos ...... in the early Golgi compartment
@nl
prefLabel
Epitope mapping of the melanos ...... in the early Golgi compartment
@ast
Epitope mapping of the melanos ...... in the early Golgi compartment
@en
Epitope mapping of the melanos ...... in the early Golgi compartment
@en-gb
Epitope mapping of the melanos ...... in the early Golgi compartment
@nl
P2093
P2860
P921
P356
P1476
Epitope mapping of the melanos ...... in the early Golgi compartment
@en
P2093
Hidenori Watabe
Julio C Valencia
Ken-ichi Yasumoto
Takeshi Kobayashi
Tsuneto Kushimoto
Vincent J Hearing
P2860
P304
P356
10.1074/JBC.M401269200
P407
P577
2004-07-02T00:00:00Z