Assembly of human frataxin is a mechanism for detoxifying redox-active iron
about
Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesChelatases: distort to select?Cryptic proteolytic activity of dihydrolipoamide dehydrogenaseErythropoietin in Friedreich ataxiaHDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse modelPorphyrin Binding and Distortion and Substrate Specificity in the Ferrochelatase Reaction: The Role of Active Site ResiduesOligomerization Propensity and Flexibility of Yeast Frataxin Studied by X-ray Crystallography and Small-Angle X-ray ScatteringThe Molecular Basis of Iron-induced Oligomerization of Frataxin and the Role of the Ferroxidation Reaction in OligomerizationIron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseasesHypoxia-inducible factor 2alpha regulates expression of the mitochondrial aconitase chaperone protein frataxinThe in vivo mitochondrial two-step maturation of human frataxin.The structure and function of frataxin.Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.The Stress-response protein prostate-associated gene 4, interacts with c-Jun and potentiates its transactivation.Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coliMitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol.Friedreich ataxia: molecular mechanisms, redox considerations, and therapeutic opportunities.Normal and Friedreich ataxia cells express different isoforms of frataxin with complementary roles in iron-sulfur cluster assemblyIron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.Metal ion substrate inhibition of ferrochelatase.The Heart in Friedreich's Ataxia: Basic Findings and Clinical Implications.Frataxin Is Localized to Both the Chloroplast and Mitochondrion and Is Involved in Chloroplast Fe-S Protein Function in ArabidopsisA Yeast/Drosophila Screen to Identify New Compounds Overcoming Frataxin DeficiencyThe Structure of the Complex between Yeast Frataxin and Ferrochelatase: CHARACTERIZATION AND PRE-STEADY STATE REACTION OF FERROUS IRON DELIVERY AND HEME SYNTHESIS.Iron chaperones for mitochondrial Fe-S cluster biosynthesis and ferritin iron storageHydrogen peroxide scavenging rescues frataxin deficiency in a Drosophila model of Friedreich's ataxia.Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia.Antioxidant use in Friedreich ataxiaAdvancements in the pathophysiology of Friedreich's Ataxia and new prospects for treatments.Friedreich ataxia: new pathways.Drosophila frataxin: an iron chaperone during cellular Fe-S cluster bioassembly.Fixing frataxin: 'ironing out' the metabolic defect in Friedreich's ataxiaMapping brain metals to evaluate therapies for neurodegenerative disease.Exploring frataxin function.Frataxin: a protein in search for a function.Binding of yeast frataxin to the scaffold for Fe-S cluster biogenesis, IsuFrataxin, a conserved mitochondrial protein, in the hydrogenosome of Trichomonas vaginalis.Human mitochondrial ferritin improves respiratory function in yeast mutants deficient in iron-sulfur cluster biogenesis, but is not a functional homologue of yeast frataxin.SAXS and stability studies of iron-induced oligomers of bacterial frataxin CyaY.The role of the N-terminal tail for the oligomerization, folding and stability of human frataxin
P2860
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P2860
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@ast
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en-gb
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@nl
type
label
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@ast
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en-gb
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@nl
prefLabel
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@ast
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en-gb
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@nl
P2093
P356
P1433
P1476
Assembly of human frataxin is a mechanism for detoxifying redox-active iron
@en
P2093
Gloria C Ferreira
Grazia Isaya
Heather A O'Neill
Matthew Sampson
Oleksandr Gakh
Steven M Mooney
Sungjo Park
P304
P356
10.1021/BI048459J
P407
P577
2005-01-18T00:00:00Z