Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a - Wikidata - thesis-toulmin - TriplyDB

Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

http://www.wikidata.org/entity/Q24537609

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Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain The Rab27a-binding protein, JFC1, regulates androgen-dependent secretion of prostate-specific antigen and prostatic-specific acid phosphatase Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes Regulation of vesicular trafficking and leukocyte function by Rab27 GTPases and their effectors Granuphilin exclusively mediates functional granule docking to the plasma membrane.Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells Neurexin-1α contributes to insulin-containing secretory granule docking Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.The Drosophila synaptotagmin-like protein bitesize is required for growth and has mRNA localization sequences within its open reading frame.Quantitative proteomic analysis of single pancreatic islets.Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.Granuphilin molecularly docks insulin granules to the fusion machinery.Secretory vesicle docking to the plasma membrane: molecular mechanism and functional significance.Increase of Calcium Sensing Receptor Expression Is Related to Compensatory Insulin Secretion during Aging in Mice.Novel aspects of the molecular mechanisms controlling insulin secretion.Molecular medicine of microRNAs: structure, function and implications for diabetes.Rab27 effectors, pleiotropic regulators in secretory pathways.The secretion of von Willebrand factor from endothelial cells; an increasingly complicated story.Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.Interplay between Rab27a effectors in pancreatic β-cells.Activated Cdc42-bound IQGAP1 determines the cellular endocytic site Luminal interaction of phogrin with carboxypeptidase E for effective targeting to secretory granules.Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a.The identification of potential factors associated with the development of type 2 diabetes: a quantitative proteomics approach Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in pancreatic islets.Long-term treatment with atrial natriuretic peptide inhibits ATP production and insulin secretion in rat pancreatic islets.The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.Modular genetic control of innate behaviors.Kinetics of Rab27a-dependent actions on vesicle docking and priming in pancreatic beta-cells.Docking is not a prerequisite but a temporal constraint for fusion of secretory granules.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

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Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a

http://www.wikidata.org/entity/Q24537609

description

2002 nî lūn-bûn

@nan

2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի օգոստոսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

@zh-hk

2002年論文

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2002年論文

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2002年论文

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name

Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

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MCB.22.15.5518-5526.2002

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Molecular and Cellular Biology

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Granuphilin modulates the exoc ...... h interaction with syntaxin 1a

@en

P2093

Seiji Torii

http://www.w3.org/2001/XMLSchema#string

Shengli Zhao

http://www.w3.org/2001/XMLSchema#string

Tetsuro Izumi

http://www.w3.org/2001/XMLSchema#string

Toshiyuki Takeuchi

http://www.w3.org/2001/XMLSchema#string

Zhaohong Yi

http://www.w3.org/2001/XMLSchema#string

P2860

Rab27a: A key to melanosome transport in human melanocytes

A conformational switch in syntaxin during exocytosis: role of munc18.

The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules

Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice

Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly

Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A

Rab proteins as membrane organizers

Initial docking of ER-derived vesicles requires Uso1p and Ypt1p but is independent of SNARE proteins

TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.

Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion.

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5518-26

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scholarly article

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4464354

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10.1128/MCB.22.15.5518-5526.2002

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15

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22

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2002-08-01T00:00:00Z

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11275491

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12101244

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133943

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