Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
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Melanoma: from melanocyte to genetic alterations and clinical optionsCDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanismsThe p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathwayRequirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C MutationCurrent State of Animal (Mouse) Modeling in Melanoma ResearchLoss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines.RB regulates pancreas development by stabilizing Pdx1Islet biology, the CDKN2A/B locus and type 2 diabetes risk.The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell massSlow and steady is the key to beta-cell replication.G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression.Genetically engineered mouse models of pituitary tumorsEstablishment of functioning human corneal endothelial cell line with high growth potential.Telomere dysfunction suppresses multiple endocrine neoplasia in mice.Cooperativity of Cdk4R24C and Ras in melanoma development.Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts.Modeling high-grade serous ovarian carcinogenesis from the fallopian tubeReversible cell cycle inhibition and premature aging features imposed by conditional expression of p16Ink4a.Exploring the tumors of multiple endocrine neoplasia type 1 in mouse models for basic and preclinical studiesOncogenes in melanoma.Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer.Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation.Association of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese women.Of mice and MEN1: Insulinomas in a conditional mouse knockout.Co-expression of p16(INK4A) and laminin 5 gamma2 by microinvasive and superficial squamous cell carcinomas in vivo and by migrating wound and senescent keratinocytes in culture.Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence.Novel ARF/p53-independent senescence pathways in cancer repression.Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1.Cyclin-Dependent Kinase Inhibitors as Anticancer TherapeuticsCDK4: A Key Player in the Cell Cycle, Development, and CancerAbsence of germline CDKN2A mutation in Sicilian patients with familial malignant melanoma: Could it be a population-specific genetic signature?Investigating the specific core genetic-and-epigenetic networks of cellular mechanisms involved in human aging in peripheral blood mononuclear cells.p16INK4a-induced senescence is disabled by melanoma-associated mutationsGenetically engineered mouse models for skin research: taking the next stepRegulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.Signaling through cyclin D-dependent kinases.Dissecting Pin1 and phospho-pRb regulation.Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
P2860
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P2860
Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Germ line transmission of the ...... scape from cellular senescence
@nl
Germ line transmission of the ...... cape from cellular senescence.
@ast
Germ line transmission of the ...... cape from cellular senescence.
@en
type
label
Germ line transmission of the ...... scape from cellular senescence
@nl
Germ line transmission of the ...... cape from cellular senescence.
@ast
Germ line transmission of the ...... cape from cellular senescence.
@en
prefLabel
Germ line transmission of the ...... scape from cellular senescence
@nl
Germ line transmission of the ...... cape from cellular senescence.
@ast
Germ line transmission of the ...... cape from cellular senescence.
@en
P2093
P2860
P1476
Germ line transmission of the ...... cape from cellular senescence.
@en
P2093
E Premkumar Reddy
Richard V Mettus
Stephen C Cosenza
Sushil G Rane
P2860
P304
P356
10.1128/MCB.22.2.644-656.2002
P407
P577
2002-01-01T00:00:00Z