Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
about
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2Role of Nrf2 in oxidative stress and toxicityCritical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activationDisruption of Nrf2 synergizes with high glucose to cause heightened myocardial oxidative stress and severe cardiomyopathy in diabetic miceNew synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressSulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?Effect of redox modulating NRF2 activators on chronic kidney diseaseOxidative stress and nucleic acid oxidation in patients with chronic kidney diseaseBiochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenesChanges in Renal Function and Oxidative Status Associated with the Hypotensive Effects of Oleanolic Acid and Related Synthetic Derivatives in Experimental AnimalsStructure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDOCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersA generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signalingSmall molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agentsRegulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disordersInflammation and coagulation markers and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA)Basic principles and emerging concepts in the redox control of transcription factorsChemical tuning enhances both potency toward nrf2 and in vitro therapeutic index of triterpenoidsImplementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathwayCell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesTriterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease.In Situ Observation of Thiol Michael Addition to a Reversible Covalent Drug in a Crystalline Sponge.Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription.Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.Nrf2: friend or foe for chemoprevention?Association of human NAD(P)H:quinone oxidoreductase 1 (NQO1) polymorphism with development of acute lung injury.Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease.Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout miceThe triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implicationsProteomic analysis shows synthetic oleanane triterpenoid binds to mTORElectrophilic tuning of the chemoprotective natural product sulforaphane.Triterpenoids CDDO-ethyl amide and CDDO-trifluoroethyl amide improve the behavioral phenotype and brain pathology in a transgenic mouse model of Huntington's diseaseDivergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.Is there a sweet spot for Nrf2 activation in the treatment of diabetic kidney disease?The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1
P2860
Q23919668-B77883F7-8967-4E95-8A3C-BFBBD9FCED01Q23919669-B0BED881-69E6-4A3E-B841-98C7F609E3B7Q23923913-59315875-8871-4DCD-8EBD-C518311B0079Q23923915-C806522B-9675-4745-A516-594FD376A765Q23923917-F3AACAEC-60FB-4408-88D5-F5EF8DC6307AQ24632281-351329B8-2B56-43E5-BEB6-33ECE6F90637Q26765790-4AABFC70-3482-429C-8037-E10476551F95Q26827726-D20FAA5B-08F3-4AF8-BE80-A441BB8A6631Q27006908-754706A6-6570-4E66-8C9E-C0B9B39C4A3FQ27023359-949EB9C8-DC56-4C4C-AD6E-47BC1BA000CEQ27305609-4A39ABA0-3CC3-46D4-A19E-39635F743DCCQ27684072-C9926770-6745-4894-86DD-B95A2B9C124CQ28384232-86FB57FF-E931-4B11-9085-B2A703FCEF50Q28385286-860638CF-DBBA-45D4-A09B-EBF4540F664CQ28386244-F80328CC-50CB-4DFA-B35A-6569837246E5Q28386313-36AC0CF1-7B46-43C5-96A9-30CB662AFF3BQ28387350-C189E238-C383-41E0-8485-D74F1F4CD822Q28391506-88094EB9-6D7B-4AA2-A8B8-11B354CBE036Q28391638-B334D773-14CF-4E7F-9CDC-1706564A4CF7Q28484275-36F20441-7898-4ACA-BAC6-481C7A66175CQ29617768-FF6B63A8-581E-4DB1-8918-C14F7F297397Q30499926-21F87DB4-83AA-432D-95D9-F931292DDC00Q31057399-8E479AEF-6D0C-4B06-A350-36359B8D317EQ33457162-75AE0694-43B1-4A27-8C86-A0DE2A768A4CQ33569389-39FEA9E2-F6AD-4D9B-9DD7-581EF7DCEEBBQ33575690-CA95BB5D-E31F-4B50-9F5E-E5E92ED8EE01Q33691297-9F6BB8D4-6D93-4C11-8259-1DDCA2FE0078Q33707090-5F36E395-8F44-49C8-AA49-BAF67203B409Q33716356-E6D302CE-180D-4DF1-98E8-82158EA94774Q33779962-21EEF345-732A-4750-BF4D-39CECE871EF9Q33838404-5276E993-613B-44AC-8904-D08461F80FFCQ33848142-5D2D3EAF-A42B-4B1A-A45E-E2B71A069E2BQ33970540-5139524B-9892-4E16-9F24-198C58DB8C95Q33983503-24BBEF18-730C-43CA-838B-E1C82A33AFFEQ34006681-5ED1D012-0299-4AF2-9F96-2DBBA69BDDCCQ34043950-9EB353F6-8402-45CD-BB05-C4F18DD22786Q34048178-98762C18-3703-4BAB-A2EC-2988CA0975A7Q34077369-8D62A436-5BE3-4403-837E-8DD683F132DAQ34175650-C65409E9-227C-4808-A5BC-0DD8DAB43545Q34231986-B65FEF0E-407B-478F-85BD-49A03D2CB547
P2860
Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Extremely potent triterpenoid ...... xidant and inflammatory stress
@ast
Extremely potent triterpenoid ...... xidant and inflammatory stress
@en
Extremely potent triterpenoid ...... xidant and inflammatory stress
@nl
type
label
Extremely potent triterpenoid ...... xidant and inflammatory stress
@ast
Extremely potent triterpenoid ...... xidant and inflammatory stress
@en
Extremely potent triterpenoid ...... xidant and inflammatory stress
@nl
prefLabel
Extremely potent triterpenoid ...... xidant and inflammatory stress
@ast
Extremely potent triterpenoid ...... xidant and inflammatory stress
@en
Extremely potent triterpenoid ...... xidant and inflammatory stress
@nl
P2093
P2860
P3181
P356
P1476
Extremely potent triterpenoid ...... xidant and inflammatory stress
@en
P2093
Charlotte Williams
Gordon W Gribble
Katherine K Stephenson
Michael B Sporn
Nanjoo Suh
Paul Talalay
Renee Risingsong
Tadashi Honda
W David Holtzclaw
Xiangqun Gao
P2860
P304
P3181
P356
10.1073/PNAS.0500815102
P407
P577
2005-03-14T00:00:00Z