Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway - Wikidata - thesis-toulmin - TriplyDB

Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway

Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway

http://www.wikidata.org/entity/Q28484275

about

The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Polyhydroxylated fullerene attenuates oxidative stress-induced apoptosis via a fortifying Nrf2-regulated cellular antioxidant defence system.Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.Worming our way to novel drug discovery with the Caenorhabditis elegans proteostasis network, stress response and insulin-signaling pathways.Role of the Nrf2 signaling system in health and disease.Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders.The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus.

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P2860

Implementation of a high-throughput screen for identifying small molecules to activate the Keap1-Nrf2-ARE pathway

http://www.wikidata.org/entity/Q28484275

description

2012 nî lūn-bûn

@nan

2012 թուականին հրատարակուած գիտական յօդուած

@hyw

2012 թվականին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

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Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

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Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

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type

label

Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

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Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

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Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

@nl

prefLabel

Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

@ast

Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

@en

Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

@nl

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JOURNAL.PONE.0044686

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Implementation of a high-throu ...... ate the Keap1-Nrf2-ARE pathway

@en

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Curtis D Klaassen

http://www.w3.org/2001/XMLSchema#string

Jie Jerry Liu

http://www.w3.org/2001/XMLSchema#string

Kai Connie Wu

http://www.w3.org/2001/XMLSchema#string

Peter R McDonald

http://www.w3.org/2001/XMLSchema#string

Rathnam Chaguturu

http://www.w3.org/2001/XMLSchema#string

P2860

A Comparison of Assay Performance Measures in Screening Assays: Signal Window, Z' Factor, and Assay Variability Ratio

Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

DNA modification by chemical carcinogens.

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e44686

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10.1371/JOURNAL.PONE.0044686

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232232770

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23056183

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High-throughput screening

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3466241

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