Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint - Wikidata - thesis-toulmin - TriplyDB

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

http://www.wikidata.org/entity/Q24563156

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p31comet blocks Mad2 activation through structural mimicry Shugoshin is a Mad1/Cdc20-like interactor of Mad2 Determinants of conformational dimerization of Mad2 and its inhibition by p31comet MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model Mad2 overexpression promotes aneuploidy and tumorigenesis in mice The multifaceted roles of the HORMA domain in cellular signaling The spindle checkpoint and chromosome segregation in meiosis TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer Structure of the mitotic checkpoint complex The APC/C subunit Mnd2/Apc15 promotes Cdc20 autoubiquitination and spindle assembly checkpoint inactivation.Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest Spatiotemporal regulation of the anaphase-promoting complex in mitosis In-silico modeling of the mitotic spindle assembly checkpoint Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.Cell division: righting the check.Regulation of mitosis and taxane response by Daxx and Rassf1.Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.RED, a spindle pole-associated protein, is required for kinetochore localization of MAD1, mitotic progression, and activation of the spindle assembly checkpoint.The influence of catalysis on mad2 activation dynamics.Evaluating putative mechanisms of the mitotic spindle checkpoint ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.Disassembly of mitotic checkpoint complexes by the joint action of the AAA-ATPase TRIP13 and p31(comet).The dynamics of signal amplification by macromolecular assemblies for the control of chromosome segregation Studying mitotic checkpoint by illustrating dynamic kinetochore protein behavior and chromosome motion in living Drosophila syncytial embryos.Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition.p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins The Cdc20-binding Phe box of the spindle checkpoint protein BubR1 maintains the mitotic checkpoint complex during mitosis.BUBR1 and closed MAD2 (C-MAD2) interact directly to assemble a functional mitotic checkpoint complex.Modeling dual pathways for the metazoan spindle assembly checkpoint.Topoisomerase IIα in chromosome instability and personalized cancer therapy.Defining pathways of spindle checkpoint silencing: functional redundancy between Cdc20 ubiquitination and p31(comet)p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment

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Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

http://www.wikidata.org/entity/Q24563156

description

2004 nî lūn-bûn

@nan

2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

name

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@ast

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@en

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@nl

type

label

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@ast

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@en

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@nl

prefLabel

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@ast

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@en

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@nl

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SJ.EMBOJ.7600322

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The EMBO Journal

P1476

Conformation-specific binding ...... Mad2 in the spindle checkpoint

@en

P2093

Guohong Xia

http://www.w3.org/2001/XMLSchema#string

Hongtao Yu

http://www.w3.org/2001/XMLSchema#string

Tomohiro Matsumoto

http://www.w3.org/2001/XMLSchema#string

Toshiyuki Habu

http://www.w3.org/2001/XMLSchema#string

Xuelian Luo

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Identification of a MAD2-binding protein, CMT2, and its role in mitosis.

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint.

Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation

Microtubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochores

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

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3133-43

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10.1038/SJ.EMBOJ.7600322

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15

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23

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2004-08-04T00:00:00Z

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8452862

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15257285

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514937

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