Mad2 overexpression promotes aneuploidy and tumorigenesis in mice - Wikidata - thesis-toulmin - TriplyDB

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

http://www.wikidata.org/entity/Q24684680

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Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis Deficient spindle assembly checkpoint in multiple myeloma MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation Loss of pRB causes centromere dysfunction and chromosomal instability Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor MTBP plays a crucial role in mitotic progression and chromosome segregation The role of aneuploidy in promoting and suppressing tumors Aneuploidy: cells losing their balance Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells When 2+2=5: the origins and fates of aneuploid and tetraploid cells Insights into APC/C: from cellular function to diseases and therapeutics Tissue Regeneration in the Chronically Inflamed Tumor Environment: Implications for Cell Fusion Driven Tumor Progression and Therapy Resistant Tumor Hybrid Cells MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation DNA damage associated with mitosis and cytokinesis failure Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis Understanding pRb: toward the necessary development of targeted treatments for retinoblastoma The role of suppressors of cytokine signalling in human neoplasms Chromosomal instability by inefficient Mps1 auto-activation due to a weakened mitotic checkpoint and lagging chromosomes Aneuploidy causes premature differentiation of neural and intestinal stem cells Excess of miRNA-378a-5p perturbs mitotic fidelity and correlates with breast cancer tumourigenesis in vivo Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies Hepatitis C Virus Induces E6AP-Dependent Degradation of the Retinoblastoma Protein Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis BCL9L Dysfunction Impairs Caspase-2 Expression Permitting Aneuploidy Tolerance in Colorectal Cancer Mad3 KEN boxes mediate both Cdc20 and Mad3 turnover, and are critical for the spindle checkpoint Increased RPA1 gene dosage affects genomic stability potentially contributing to 17p13.3 duplication syndrome Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia Targeting the adaptability of heterogeneous aneuploids Identification of genes that are essential to restrict genome duplication to once per cell division The causes and consequences of genetic heterogeneity in cancer evolution Multiple cancer testis antigens function to support tumor cell mitotic fidelity.A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor Human cancer cells commonly acquire DNA damage during mitotic arrest.The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint Persistent telomere damage induces bypass of mitosis and tetraploidy.

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P2860

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

http://www.wikidata.org/entity/Q24684680

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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type

label

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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J.CCR.2006.10.019

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

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Carlos Cordón-Cardo

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Elena Díaz-Rodríguez

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Robert Benezra

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Scott W Lowe

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P2860

Identification of a MAD2-binding protein, CMT2, and its role in mitosis.

High-resolution genomic profiles of human lung cancer

The role of chromosomal instability in tumor initiation.

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation

MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Gene expression profiling predicts clinical outcome of breast cancer

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

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10.1016/J.CCR.2006.10.019

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1

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11

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Julie Teruya-Feldstein

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6610317

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