Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 - Wikidata - thesis-toulmin - TriplyDB

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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Update on the Kelch-like (KLHL) gene family The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Role of Nrf2 in oxidative stress and toxicity Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer Critical cysteine residues of Kelch-like ECH-associated protein 1 in arsenic sensing and suppression of nuclear factor erythroid 2-related factor 2 The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2 Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells Regulation of Cullin-RING ubiquitin ligase 1 by Spliceosome-associated protein 130 (SAP130)Control of rapsyn stability by the CUL-3-containing E3 ligase complex Ubiquitin ligase activity of Cul3-KLHL7 protein is attenuated by autosomal dominant retinitis pigmentosa causative mutation Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Cysteine-based regulation of the CUL3 adaptor protein Keap1 Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction Heme induces ubiquitination and degradation of the transcription factor Bach1 Sequence and structural analysis of BTB domain proteins The Role of Omega-3 Polyunsaturated Fatty Acids in Stroke Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics Reactive oxygen species and mitochondria: A nexus of cellular homeostasis Overview of Nrf2 as Therapeutic Target in Epilepsy

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

http://www.wikidata.org/entity/Q24563807

description

2004 nî lūn-bûn

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2004 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի օգոստոսին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

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MCB.24.16.7130-7139.2004

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Molecular and Cellular Biology

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Oxidative stress sensor Keap1 ...... roteasomal degradation of Nrf2

@en

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Hiromi Okawa

http://www.w3.org/2001/XMLSchema#string

Makiko Ohtsuji

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Masayuki Yamamoto

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Moon-Il Kang

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Tomoki Chiba

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Yukari Zenke

http://www.w3.org/2001/XMLSchema#string

P2860

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival

The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

The ubiquitin system

Covalent modification of all members of human cullin family proteins by NEDD8

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

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7130-9

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459199

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10.1128/MCB.24.16.7130-7139.2004

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16

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24

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Kazuhiko Igarashi

Akira Kobayashi

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2004-08-01T00:00:00Z

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8428290

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15282312

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Nuclear factor, erythroid derived 2, like 2

Kelch-like ECH-associated protein 1

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479737

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