The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm - Wikidata - thesis-toulmin - TriplyDB

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

http://www.wikidata.org/entity/Q28216217

about

sameAs

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2 Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Nuclear transport, oxidative stress, and neurodegeneration Cysteine-based regulation of the CUL3 adaptor protein Keap1 Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals The Role of Cyclo(His-Pro) in Neurodegeneration Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - implication in modification of radiation damage Redox control of microglial function: molecular mechanisms and functional significance Structural analysis of the complex of Keap1 with a prothymosin α peptide Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Kelch proteins: emerging roles in skeletal muscle development and diseases.Discovery of direct inhibitors of Keap1-Nrf2 protein-protein interaction as potential therapeutic and preventive agents Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling Mechanistic studies of the Nrf2-Keap1 signaling pathway Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria Stress-activated cap'n'collar transcription factors in aging and human disease Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review Antiapoptotic Effects of EGb 761 Regulation of Nrf2-an update Basic principles and emerging concepts in the redox control of transcription factors Nrf2 signaling and cell survival Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

P2860

Q23919668-AEA694CF-6405-445E-892D-561837233FD5 Q24298930-0497C6AB-CCA6-47F6-9AFA-3CB7C6F4BA5C Q24323175-188F3A0E-E5DD-426D-8622-8E7436FB1CF1 Q24558689-78FFD3EE-529A-481C-B020-F797989C094D Q24559743-7B625729-B013-4273-BAF6-F1400E058783 Q24563807-AF82D85D-550D-4D47-A96A-864F8191BBA9 Q24624357-0A1FE3E5-A346-46C9-B026-F1289805E950 Q24629359-8252C39E-8CF6-4246-A21B-51EC11F2FE21 Q24646029-70939054-F4E7-4800-8FA3-F9C886AC3E0F Q24653078-FFF909F4-A6CC-4096-B217-6A51D92F41DB Q24655442-496C5546-12EE-4579-B07D-9CD5A8304180 Q24804994-CDF01DBC-775D-4BC2-BE18-F823387A93D6 Q26741190-5D948202-999B-4464-BFC0-3C9788C49E2B Q26774916-06D636F0-6258-4A64-B9E5-FD9995A209A8 Q26822972-30D8A19A-1893-4788-851D-C21040CCA327 Q26995211-6550F117-60F0-405C-AF29-6BB9BD984A6C Q27000279-755CAC34-C65E-4145-B9EE-EFE35251E8C2 Q27650252-6ACC6D2E-DA4E-40B5-B607-303C58182D3A Q27684072-78E51D4D-019F-4C68-ADAA-AEF96FF36C25 Q27687474-8B8146AD-73E1-4F36-95B5-A6E8FF7507EC Q28085561-C266B320-48D0-4194-8279-1767BC8BB9EF Q28085631-D768D8E3-DD17-46BF-BF27-AF1AD7ECD30B Q28116515-E85DBE76-89F1-4D4E-B1C7-86F64A239F0D Q28255526-B7C08457-9424-4F96-A3D4-C29B6D8F560E Q28277182-CF01D18B-1572-41EF-AB1F-5A655E075C75 Q28283167-F50B2586-3FC1-4E40-8CE5-049E7ED3EB91 Q28384349-1E604840-2D1F-4793-87AA-364788951343 Q28384526-8AEE35DF-CE47-49B5-B0BE-9E27AABDEE85 Q28384783-26608149-706F-4772-A4A3-36D203D70CB8 Q28386244-F86C12A7-D4EC-4204-BB1B-38EF960EABAB Q28386665-D19DAC1B-7359-4326-8C11-E4E11E432DEC Q28387384-78F74FD2-F06E-4F64-9ACE-1D90149714A5 Q28388589-1306D0FF-F258-463D-B74F-325B85F76DB2 Q28391506-BB3FF2F1-CAD0-4551-A04F-C52D3791E2AE Q28394210-C2C70ED9-2B23-4804-BC56-FE6EE732E5D2 Q28396785-4E393D3B-2A54-49C9-BEF3-02F9A3044385 Q28574082-CFBA6160-E8D4-4369-A607-6F8239781AAF Q28593237-7F4E87C5-F731-46C4-857E-970408EF7BE7 Q28817936-E5CBD980-89A7-4993-872A-82CA4FE7CCE4 Q28910182-3D9D2861-62C8-4973-83E7-25409B78327D

P2860

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

http://www.wikidata.org/entity/Q28216217

description

2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

article publié dans la revue scientifique Journal of Biological Chemistry

@fr

artículu científicu espublizáu en 2002

@ast

im September 2002 veröffentlichter wissenschaftlicher Artikel

@de

scientific article (publication date: 27 September 2002)

@en

vedecký článok (publikovaný 2002/09/27)

@sk

vědecký článek publikovaný v roce 2002

@cs

wetenschappelijk artikel (gepubliceerd op 2002/09/27)

@nl

наукова стаття, опублікована у вересні 2002

@uk

name

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@ast

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@en

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@nl

type

label

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@ast

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@en

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@nl

prefLabel

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@ast

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@en

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@nl

P1433

Q28216217-55D91F09-E87E-4EF4-8246-9594743DDC56

P1476

Q28216217-9729A88A-91F0-48B1-9D65-D1D80F74D710

P2093

Q28216217-C0C22813-24DF-46D5-9F4A-54F5072DABFD

Q28216217-CF84151E-9B49-4894-8B58-F86C4D2676DD

P2860

Q28216217-0591C3EC-6B2A-4022-A25E-2C6CEDF2E572

Q28216217-073473FC-7F1E-40DE-B4D7-6E9E82540617

Q28216217-13D326D6-DDFB-47D0-8920-C13A09720AFB

Q28216217-1A342FDA-082A-4931-A45E-3D38F7EFCABB

Q28216217-23CC5E05-E5CC-4422-AD38-840339BC6BDD

Q28216217-245FE9E1-3DDD-4898-8C96-1F7F9F36B1AE

Q28216217-2B7B8C3A-B6FD-46B9-BA75-36884C5016E4

Q28216217-2BA58F0B-3963-4BE9-BD53-B69CF4570881

Q28216217-2D4CFAD2-0B20-4929-8B69-C734226B545B

Q28216217-34090DCE-589A-454F-B91F-34B0BA618E26

P304

Q28216217-5227C74C-99CE-4689-BEB3-2BF54071E7F8

P31

Q28216217-CBA72463-14C3-40ED-A45E-A5CC7AA74402

P3181

Q28216217-B2AB8215-5862-4714-AD67-935C24328FF1

P356

Q28216217-E4071D0D-5997-42B6-9DC1-5AF8E67476A6

P407

Q28216217-BCCF698D-AFE9-47E7-BA91-2C7FE782C6BE

P433

Q28216217-D3A43FDF-777C-4DE1-819F-A3255B372E06

P478

Q28216217-AAE59F91-0C5D-4511-914A-0B1F93127369

P577

Q28216217-12DADCC5-1915-4BF0-A3E9-FACA4778BD06

P698

Q28216217-40556876-2F94-48FF-BF72-1791CEC6AB67

P3181

P356

P1433

Journal of Biological Chemistry

P1476

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

@en

P2093

Laurie M Zipper

http://www.w3.org/2001/XMLSchema#string

R Timothy Mulcahy

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the BTB domain from PLZF

Isolation and characterization of IPP, a novel human gene encoding an actin-binding, kelch-like protein

Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain

Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

The POZ domain: a conserved protein-protein interaction motif

Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene

The kelch repeat superfamily of proteins: propellers of cell function

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

P304

36544-52

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4097707

http://www.w3.org/2001/XMLSchema#string

P356

10.1074/JBC.M206530200

http://www.w3.org/2001/XMLSchema#string

P407

P433

39

http://www.w3.org/2001/XMLSchema#string

P478

277

http://www.w3.org/2001/XMLSchema#string

P577

2002-09-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

12145307

http://www.w3.org/2001/XMLSchema#string