Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia - Wikidata - thesis-toulmin - TriplyDB

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

http://www.wikidata.org/entity/Q24597256

about

Musashi2 is required for the self-renewal and pluripotency of embryonic stem cells Functional Integration of mRNA Translational Control Programs Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions Molecular evolution of Zika virus as it crossed the Pacific to the Americas Asymmetric cell division of stem and progenitor cells during homeostasis and cancer A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.Genomic data integration in chronic lymphocytic leukemia.Proteomic Analysis Reveals Autophagy as Pro-Survival Pathway Elicited by Long-Term Exposure with 5-Azacitidine in High-Risk Myelodysplasia.Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2 Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.New frontiers in translational control of the cancer genome Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite.Inactivation of a single copy of Crebbp selectively alters pre-mRNA processing in mouse hematopoietic stem cells.A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in hematopoietic stem cells AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis.Drosophila Rbp6 is an orthologue of vertebrate Msi-1 and Msi-2, but does not function redundantly with dMsi to regulate germline stem cell behaviour Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain-containing m-Numb protein expression in regenerating gastric mucosa.Multi-disciplinary methods to define RNA-protein interactions and regulatory networks Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation.The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells A conserved three-nucleotide core motif defines Musashi RNA binding specificity From Hen House to Bedside: Tracing Hanafusa's Legacy from Avian Leukemia Viruses to SRC to ABL and Beyond Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.Neural stem and progenitor cell fate transition requires regulation of Musashi1 function.Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients.UMG Lenti: novel lentiviral vectors for efficient transgene- and reporter gene expression in human early hematopoietic progenitors.Musashi-2 Silencing Exerts Potent Activity against Acute Myeloid Leukemia and Enhances Chemosensitivity to Daunorubicin RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.Identifying Network Perturbation in Cancer.A novel TTC40-MSI2 fusion in de novo acute myeloid leukemia with an unbalanced 10;17 translocation.Integrating multiple molecular sources into a clinical risk prediction signature by extracting complementary information.

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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

http://www.wikidata.org/entity/Q24597256

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@ast

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@en

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@nl

type

label

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@ast

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@en

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@nl

prefLabel

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@ast

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@en

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

@nl

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Nature Medicine

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Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

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Benjamin L Ebert

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Brian Ball

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Claudia Scholl

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D Gary Gilliland

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Fatima Al-Shahrour

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Kelly Morgan

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Lars Bullinger

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Mahnaz Paktinat

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Maricel Gozo

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Michael G Kharas

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P2860

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA

Cancerous stem cells can arise from pediatric brain tumors

RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Oncogenic pathway signatures in human cancers as a guide to targeted therapies

Imaging hematopoietic precursor division in real time.

Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors

Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

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903-8

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1868759

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10.1038/NM.2187

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8

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16

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Christopher J. Lengner

George Q. Daley

Rudolf Jaenisch

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2010-08-01T00:00:00Z

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45114304

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1012359172

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20616797

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3090658

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