AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias - Wikidata - thesis-toulmin - TriplyDB

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

http://www.wikidata.org/entity/Q34212654

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The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer The Tumorigenic Roles of the Cellular REDOX Regulatory Systems The Potential of Vitamin D-Regulated Intracellular Signaling Pathways as Targets for Myeloid Leukemia Therapy Harnessing the apoptotic programs in cancer stem-like cells FOXO transcription factors: key regulators of cellular quality control Concise review: Leukemia stem cells in personalized medicine FOXO3: A Major Gene for Human Longevity--A Mini-Review Cell-nonautonomous signaling of FOXO/DAF-16 to the stem cells of Caenorhabditis elegans Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cells RUNX1 and its understudied role in breast cancer Anti-CD44 antibodies inhibit both mTORC1 and mTORC2: a new rationale supporting CD44-induced AML differentiation therapy.Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML.Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression Transient TNF regulates the self-renewing capacity of stem-like label-retaining cells in sphere and skin equivalent models of melanoma.Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells.Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition.EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells Akt-signal integration is involved in the differentiation of embryonal carcinoma cells Telomerase inhibition effectively targets mouse and human AML stem cells and delays relapse following chemotherapy.DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.Regulation of cell cycle progression by forkhead transcription factor FOXO3 through its binding partner DNA replication factor Cdt1.mTORC1 is essential for leukemia propagation but not stem cell self-renewal.Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3.Misfolded N-CoR is Linked to the Ectopic Reactivation of CD34/Flt3-Based Stem-Cell Phenotype in Promyelocytic and Monocytic Acute Myeloid Leukemia Longevity Genes Revealed by Integrative Analysis of Isoform-Specific daf-16/FoxO Mutants of Caenorhabditis elegans AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow FOXO1 inhibits osteoclastogenesis partially by antagnozing MYC.Phosphorylation of GSK3α/β correlates with activation of AKT and is prognostic for poor overall survival in acute myeloid leukemia patients.Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia C. elegans DAF-16/FOXO interacts with TGF-ß/BMP signaling to induce germline tumor formation via mTORC1 activation FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice Retinoid X Receptor-selective Signaling in the Regulation of Akt/Protein Kinase B Isoform-specific Expression.Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia.FOXO1 inhibits osteosarcoma oncogenesis via Wnt/β-catenin pathway suppression.Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

http://www.wikidata.org/entity/Q34212654

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@ast

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@en

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@nl

type

label

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@ast

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@en

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@nl

prefLabel

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@ast

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@en

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@nl

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J.CELL.2011.07.032

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AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias

@en

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Borja Saez

http://www.w3.org/2001/XMLSchema#string

Claudia Scholl

http://www.w3.org/2001/XMLSchema#string

D Gary Gilliland

http://www.w3.org/2001/XMLSchema#string

David T Scadden

http://www.w3.org/2001/XMLSchema#string

Demetrios Kalaitzidis

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Eyal C Attar

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Francesca Ferraro

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Francois Mercier

http://www.w3.org/2001/XMLSchema#string

Harshabad Singh

http://www.w3.org/2001/XMLSchema#string

Kristina M Brumme

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Mechanism of activation of protein kinase B by insulin and IGF-1

Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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697-708

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scholarly article

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10.1016/J.CELL.2011.07.032

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5

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146

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2011-09-01T00:00:00Z

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51613210

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21884932

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3826540

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