Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines - Wikidata - thesis-toulmin - TriplyDB

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

http://www.wikidata.org/entity/Q24598853

about

Recent developments in Alzheimer's disease therapeutics Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration GSPE interferes with tau aggregation in vivo: implication for treating tauopathy Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease NMR Meets Tau: Insights into Its Function and Pathology Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies Imaging Multimodalities for Dissecting Alzheimer's Disease: Advanced Technologies of Positron Emission Tomography and Fluorescence Imaging Combotherapy and current concepts as well as future strategies for the treatment of Alzheimer's disease Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets Neural stem cells could serve as a therapeutic material for age-related neurodegenerative diseases Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio Tau Biology and Tau-Directed Therapies for Alzheimer's Disease The Role of MAPT in Neurodegenerative Diseases: Genetics, Mechanisms and Therapy Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Methylene blue reduced abnormal tau accumulation in P301L tau transgenic mice Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway Tau-mediated neurodegeneration in Alzheimer's disease and related disorders Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells: A Potentially Novel Therapeutic Mechanism of a Therapeutic Approach in the Treatment of Alzheimer's Disease.Structural determinants of Tau aggregation inhibitor potency Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer's disease and frontotemporal lobar degeneration What happens in the brain of schizophrenia patients?: an investigation from the viewpoint of neuropathology.Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau.Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells.High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors.Targeting Abeta and tau in Alzheimer's disease, an early interim report Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation.Progress in Alzheimer's disease.Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials Current treatment and recent clinical research in Alzheimer's disease Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models Peptides for therapy and diagnosis of Alzheimer's disease.Development of a grape seed polyphenolic extract with anti-oligomeric activity as a novel treatment in progressive supranuclear palsy and other tauopathies Current and emerging drug treatment options for Alzheimer's disease: a systematic review.Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.Cellular and molecular actions of Methylene Blue in the nervous system Methylene blue modulates β-secretase, reverses cerebral amyloidosis, and improves cognition in transgenic mice.

P2860

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P2860

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

http://www.wikidata.org/entity/Q24598853

description

1996 nî lūn-bûn

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1996 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի հոտեմբերին հրատարակված գիտական հոդված

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@ast

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@en

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@nl

type

label

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@ast

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@en

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@nl

prefLabel

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@ast

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@en

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

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C M Wischik

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M Roth

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P C Edwards

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R Y Lai

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P2860

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

Structural characterization of the core of the paired helical filament of Alzheimer disease.

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

Molecular analysis of neurofibrillary degeneration in Alzheimer's disease. An immunohistochemical study.

Biochemical and anatomical redistribution of tau protein in Alzheimer's disease.

Influence of apolipoprotein E genotype on senile dementia of the Alzheimer and Lewy body types. Significance for etiological theories of Alzheimer's disease.

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20

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Charles Harrington

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Alzheimer's disease

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