Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets - Wikidata - thesis-toulmin - TriplyDB

Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets

Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets

http://www.wikidata.org/entity/Q26865654

about

Epidemiology of Alzheimer disease Clinical utility and analytical challenges in measurement of cerebrospinal fluid amyloid-β(1-42) and τ proteins as Alzheimer disease biomarkers Blood biomarkers for brain injury: What are we measuring?Tau physiology and pathomechanisms in frontotemporal lobar degeneration 3D culture models of Alzheimer's disease: a road map to a "cure-in-a-dish"Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity.Neuroprotective Functions for the Histone Deacetylase SIRT6 PINCH in the cellular stress response to tau-hyperphosphorylation.Role of cerebrospinal fluid biomarkers in clinical trials for Alzheimer's disease modifying therapies In vitro aggregation assays using hyperphosphorylated tau protein.Deciphering Alzheimer disease.The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy.Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies Activity Based High-Throughput Screening for Novel O-GlcNAc Transferase Substrates Using a Dynamic Peptide Microarray Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Alzheimer's disease in a dish: promises and challenges of human stem cell models.Tauopathies as clinicopathological entities.Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy.Can MRI screen for CSF biomarkers in neurodegenerative disease?Characterization of Brain-Penetrant Pyrimidine-Containing Molecules with Differential Microtubule-Stabilizing Activities Developed as Potential Therapeutic Agents for Alzheimer's Disease and Related Tauopathies EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer's disease.Ablation of Prion Protein in Wild Type Human Amyloid Precursor Protein (APP) Transgenic Mice Does Not Alter The Proteolysis of APP, Levels of Amyloid-β or Pathologic Phenotype NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities.Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations Biochemistry and cell biology of tau protein in neurofibrillary degeneration Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.Alzheimer disease in 2020.Advances in quantitative structure-activity relationship models of anti-Alzheimer's agents.Cellular factors modulating the mechanism of tau protein aggregation.The Role of Cerebrospinal Fluid Biomarkers in the Evolution of Diagnostic Criteria in Alzheimer's Disease: Shortcomings in Prodromal Diagnosis.Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.Therapeutic Strategies for Restoring Tau Homeostasis.An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.Cerebrospinal Fluid Biomarkers in Alzheimer's Disease-From Brain Starch to Bench and Bedside.Primary or secondary prevention for AD: who cares?Role of Tau Acetylation in Alzheimer's Disease and Chronic Traumatic Encephalopathy: The Way Forward for Successful Treatment.

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Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets

http://www.wikidata.org/entity/Q26865654

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Developing therapeutic approac ...... lated neuronal protein targets

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Developing therapeutic approac ...... lated neuronal protein targets

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Developing therapeutic approac ...... lated neuronal protein targets

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type

label

Developing therapeutic approac ...... lated neuronal protein targets

@ast

Developing therapeutic approac ...... lated neuronal protein targets

@en

Developing therapeutic approac ...... lated neuronal protein targets

@nl

prefLabel

Developing therapeutic approac ...... lated neuronal protein targets

@ast

Developing therapeutic approac ...... lated neuronal protein targets

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Developing therapeutic approac ...... lated neuronal protein targets

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CSHPERSPECT.A006437

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Cold Spring Harbor Perspectives in Medicine

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Developing therapeutic approac ...... lated neuronal protein targets

@en

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J. Q. Trojanowski

http://www.w3.org/2001/XMLSchema#string

K. R. Brunden

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M. Hutton

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V. M.-Y. Lee

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Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

Glycogen synthase kinase 3: more than a namesake

Repeat motifs of tau bind to the insides of microtubules in the absence of taxol

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

Lysine acetylation: codified crosstalk with other posttranslational modifications

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway

Transmission and spreading of tauopathy in transgenic mouse brain

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a006437

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scholarly article

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4443697

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10.1101/CSHPERSPECT.A006437

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1

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221732948

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22229117

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3234455

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