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Eukaryotic DNA ligases: structural and functional insights

Eukaryotic DNA ligases: structural and functional insights

http://www.wikidata.org/entity/Q24617266

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DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells A high-throughput scintillation proximity-based assay for human DNA ligase IV Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells DNA ligase III: a spotty presence in eukaryotes, but an essential function where tested Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency Functional redundancy between DNA ligases I and III in DNA replication in vertebrate cells DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1)Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1 The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease The current state of eukaryotic DNA base damage and repair From Structure-Function Analyses to Protein Engineering for Practical Applications of DNA Ligase Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.The structural basis of XRCC1-mediated DNA repair Role of non-homologous end joining in V(D)J recombination Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS Biochemical and Structural Characterisation of DNA Ligases from Bacteria and Archaea The multi-replication protein A (RPA) system--a new perspective.Limiting the persistence of a chromosome break diminishes its mutagenic potential.Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity.DNA polymerase β contains a functional nuclear localization signal at its N-terminus.Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry.Iron mediates catalysis of nucleic acid processing enzymes: support for Fe(II) as a cofactor before the great oxidation event.Nonhomologous end joining: a good solution for bad ends Cellular DNA ligase I is recruited to cytoplasmic vaccinia virus factories and masks the role of the vaccinia ligase in viral DNA replication.

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Eukaryotic DNA ligases: structural and functional insights

http://www.wikidata.org/entity/Q24617266

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2008 nî lūn-bûn

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2008 թվականին հրատարակված գիտական հոդված

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2008年の論文

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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Eukaryotic DNA ligases: structural and functional insights

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ANNUREV.BIOCHEM.77.061306.123941

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Annual Review of Biochemistry

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Eukaryotic DNA ligases: structural and functional insights

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Alan E Tomkinson

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P2860

DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes

The human DNA ligase III gene encodes nuclear and mitochondrial proteins

Crystal structure of an Xrcc4-DNA ligase IV complex

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae

Actions of aprataxin in multiple DNA repair pathways

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

Large-scale characterization of HeLa cell nuclear phosphoproteins

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313-38

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10.1146/ANNUREV.BIOCHEM.77.061306.123941

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1

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Tom Ellenberger

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