Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity - Wikidata - thesis-toulmin - TriplyDB

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

http://www.wikidata.org/entity/Q27681030

about

DNA polymerase ε and its roles in genome stability Ribonucleotides in bacterial DNA Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2{middle dot}DNA and Top2{middle dot}RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)The structural basis of XRCC1-mediated DNA repair Role of ALADIN in human adrenocortical cells for oxidative stress response and steroidogenesis Topoisomerase I alone is sufficient to produce short DNA deletions and can also reverse nicks at ribonucleotide sites Genetic instability in budding and fission yeast-sources and mechanisms Eukaryotic genome instability in light of asymmetric DNA replication Ribonucleotides in DNA: Origins, repair and consequences Processing ribonucleotides incorporated during eukaryotic DNA replication.Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends.How the misincorporation of ribonucleotides into genomic DNA can be both harmful and helpful to cells Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.Neurological disorders associated with DNA strand-break processing enzymes.Recognition and repair of chemically heterogeneous structures at DNA ends Impact of template backbone heterogeneity on RNA polymerase II transcription.Effects of DNA3'pp5'G capping on 3' end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance.Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition.Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.A fluorescent HTS assay for phosphohydrolases based on nucleoside 5'-fluorophosphates: its application in screening for inhibitors of mRNA decapping scavenger and PDE-I.RNA damage in biological conflicts and the diversity of responding RNA repair systems Ribonucleotide triggered DNA damage and RNA-DNA damage responses Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3.APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific.Incision of damaged DNA in the presence of an impaired Smc5/6 complex imperils genome stability The role of DNA base excision repair in brain homeostasis and disease.Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.Genome instabilities arising from ribonucleotides in DNA.Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq.Kinetics of T3-DNA Ligase-Catalyzed Phosphodiester Bond Formation Measured Using the α-Hemolysin Nanopore.Genome integrity and disease prevention in the nervous system.Topoisomerase I-mediated cleavage at unrepaired ribonucleotides generates DNA double-strand breaks.The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation.Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.Synthesis of novel pyrophosphorothiolate-linked dinucleoside cap analogues in a ball mill.Clinical, Biomarker, and Molecular Delineations and Genotype-Phenotype Correlations of Ataxia With Oculomotor Apraxia Type 1.

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Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

http://www.wikidata.org/entity/Q27681030

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@ast

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@en

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@nl

type

label

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@ast

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@en

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@nl

prefLabel

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@ast

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

@en

Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

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Aprataxin resolves adenylated RNA–DNA junctions to maintain genome integrity

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Jessica S Williams

http://www.w3.org/2001/XMLSchema#string

Matthew J Schellenberg

http://www.w3.org/2001/XMLSchema#string

Percy Tumbale

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R Scott Williams

http://www.w3.org/2001/XMLSchema#string

P2860

Actions of aprataxin in multiple DNA repair pathways

The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

Aprataxin forms a discrete branch in the HIT (histidine triad) superfamily of proteins with both DNA/RNA binding and nucleotide hydrolase activities

Structure-based analysis of catalysis and substrate definition in the HIT protein family

Eukaryotic DNA ligases: structural and functional insights

Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states

Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Watching DNA polymerase η make a phosphodiester bond

Structure of an aprataxin–DNA complex with insights into AOA1 neurodegenerative disease

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10.1038/NATURE12824

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506

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Thomas A Kunkel

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2014-02-06T00:00:00Z

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259449319

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24362567

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4064939

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