Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia - Wikidata - thesis-toulmin - TriplyDB

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

http://www.wikidata.org/entity/Q24626212

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An enigmatic fourth runt domain gene in the fugu genome: ancestral gene loss versus accelerated evolution A novel transcript encoding an N-terminally truncated AML1/PEBP2 alphaB protein interferes with transactivation and blocks granulocytic differentiation of 32Dcl3 myeloid cells Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1 Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1 Association of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome Familial mutations of the transcription factor RUNX1 (AML1, CBFA2) predispose to acute myeloid leukemia RUNX1 truncation resulting from a cryptic and novel t(6;21)(q25;q22) chromosome translocation in acute myeloid leukemia: A case report RUNX1 and its understudied role in breast cancer The common retroviral insertion locus Dsi1 maps 30 kilobases upstream of the P1 promoter of the murine Runx3/Cbfa3/Aml2 gene Allele-specific KRT1 expression is a complex trait.Identification of a new pebp2alphaA2 isoform from zebrafish runx2 capable of inducing osteocalcin gene expression in vitro.Mouse RUNX1C regulates premegakaryocytic/erythroid output and maintains survival of megakaryocyte progenitors.Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events.Runx1 exon 6-related alternative splicing isoforms differentially regulate hematopoiesis in mice Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1 Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.Transcription-coupled translation control of AML1/RUNX1 is mediated by cap- and internal ribosome entry site-dependent mechanisms.Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3.Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.Identification of a novel circularized transcript of the AML1 gene Links among growth factors, hormones, and nuclear factors with essential roles in bone formation.SARS coronavirus 3b accessory protein modulates transcriptional activity of RUNX1b.AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML.Functionally deregulated AML1/RUNX1 cooperates with BCR-ABL to induce a blastic phase-like phenotype of chronic myelogenous leukemia in mice.AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex Runx3 knockouts and stomach cancer RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis.Transcriptional Auto-Regulation of RUNX1 P1 Promoter.Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors.Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia.Cell cycle and developmental control of hematopoiesis by Runx1.Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene

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Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia

http://www.wikidata.org/entity/Q24626212

description

1995 nî lūn-bûn

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1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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1995 թվականի հուլիսին հրատարակված գիտական հոդված

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1995年の論文

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1995年論文

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1995年論文

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1995年論文

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1995年論文

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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Alternative splicing and genom ...... lved in acute myeloid leukemia

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P2860

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation

Organization and expression of eucaryotic split genes coding for proteins

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction

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3389277

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10.1093/NAR/23.14.2762

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14

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