The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
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Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemiasAtrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO/MTG8 in the nuclear matrix and represses transcriptionThe transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respirationSubcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBFThe AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion proteinETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressorsThe ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger proteinETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domainOligomerization of ETO is obligatory for corepressor interactionDEAF-1, a novel protein that binds an essential region in a Deformed response elementDisruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesisGeneration of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemiaAlternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemiaETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complexMolecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cellsMolecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling UnitsCore Binding Factor Acute Myeloid Leukemia: New Prognostic Categories and Therapeutic OpportunitiesStructural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activityA stable transcription factor complex nucleated by oligomeric AML1–ETO controls leukaemogenesisAssociation of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell linesCo-repressor CBFA2T2 regulates pluripotency and germline developmentExpression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic developmentMtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine.FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levelsAML1 is expressed in skeletal muscle and is regulated by innervationAbsence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression.Novel RNA-binding properties of the MTG chromatin regulatory proteins.The leukemia associated ETO nuclear repressor gene is regulated by the GATA-1 transcription factor in erythroid/megakaryocytic cells.Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expressionIntegrity of a Zn finger-like domain in SamB is crucial for morphogenesis in ascomycetous fungi.Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation.AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.Both TEL and AML-1 contribute repression domains to the t(12;21) fusion protein.Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy.Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation
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P2860
The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
description
1993 nî lūn-bûn
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1993 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հուլիսին հրատարակված գիտական հոդված
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1993年の論文
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1993年論文
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1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
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1993年論文
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1993年论文
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name
The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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The t(8;21) translocation in a ...... an AML1-MTG8 fusion transcript
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1993-07-01T00:00:00Z