Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain
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Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistanceHomozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature.Dominant-negative retinoic acid receptors elicit epidermal defects through a non-canonical pathwayThyroid hormone signaling in vivo requires a balance between coactivators and corepressorsNuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signalingAn unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesisPhenotypic variability in patients with generalised resistance to thyroid hormone.Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinomaLessons from mouse models of thyroid cancer.An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype.Genomic profiling of genes contributing to metastasis in a mouse model of thyroid follicular carcinoma.Differential expression of mutant and normal beta T3 receptor alleles in kindreds with generalized resistance to thyroid hormone.Interaction of human beta 1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor beta. T3 response element-dependent dominant negative potencyDual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone.Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.Thyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action.Tumor suppressor action of liganded thyroid hormone receptor beta by direct repression of beta-catenin gene expression.Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta geneActivation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor.Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activityActivation of integrin-ERBB2 signaling in undifferentiated thyroid cancer.Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expressionOncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer.Global expression profiling reveals gain-of-function oncogenic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis.Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: evidence for TR isoform-specific transcriptional regulation in vivoDifferential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.Hyperactivity and learning deficits in transgenic mice bearing a human mutant thyroid hormone beta1 receptor geneAberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.Extranuclear signaling of mutated thyroid hormone receptors in promoting metastatic spread in thyroid carcinogenesisThyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosisHormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptors.Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone.Mutations in the ligand-binding domain of the androgen receptor gene cluster in two regions of the gene.Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 familiesImpaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors.
P2860
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P2860
Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain
description
1991 nî lūn-bûn
@nan
1991 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1991 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
name
Characterization of seven nove ...... s of the ligand binding domain
@ast
Characterization of seven nove ...... s of the ligand binding domain
@en
Characterization of seven nove ...... s of the ligand binding domain
@nl
type
label
Characterization of seven nove ...... s of the ligand binding domain
@ast
Characterization of seven nove ...... s of the ligand binding domain
@en
Characterization of seven nove ...... s of the ligand binding domain
@nl
prefLabel
Characterization of seven nove ...... s of the ligand binding domain
@ast
Characterization of seven nove ...... s of the ligand binding domain
@en
Characterization of seven nove ...... s of the ligand binding domain
@nl
P2093
P2860
P3181
P356
P1476
Characterization of seven nove ...... s of the ligand binding domain
@en
P2093
A J Mixson
B D Weintraub
J A McPherson
J H McClaskey
R Parrilla
P2860
P304
P3181
P356
10.1172/JCI115542
P407
P577
1991-12-01T00:00:00Z