An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis
about
Molecular aspects of thyroid hormone actionsCellular and molecular basis of deiodinase-regulated thyroid hormone signalingNuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signalingThyroid hormone receptors mutated in liver cancer function as distorted antimorphsHypothyroidism enhances tumor invasiveness and metastasis development.A Patient With a Thyrotropin-Secreting Microadenoma and Resistance to Thyroid Hormone (P453T).Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinomaDual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone.Mechanisms of thyroid hormone actionActivation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor.Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.Src-dependent phosphorylation at Y406 on the thyroid hormone receptor β confers the tumor suppressor activitySonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.Activation of integrin-ERBB2 signaling in undifferentiated thyroid cancer.Global expression profiling reveals gain-of-function oncogenic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis.Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.Thyroid hormone receptor mutations in cancer and resistance to thyroid hormone: perspective and prognosisResistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).Impaired adipogenesis caused by a mutated thyroid hormone alpha1 receptor.SKI-606, an Src inhibitor, reduces tumor growth, invasion, and distant metastasis in a mouse model of thyroid cancerModeling follicular thyroid cancer for future therapiesAdvanced bone formation in mice with a dominant-negative mutation in the thyroid hormone receptor β gene due to activation of Wnt/β-catenin protein signaling.Thyroid hormone receptors and cancer.Thyroid hormone receptors are tumor suppressors in a mouse model of metastatic follicular thyroid carcinomaPTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer.Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumorsInhibition of STAT3 activity delays obesity-induced thyroid carcinogenesis in a mouse model.Role of TSH in the spontaneous development of asymmetrical thyroid carcinoma in mice with a targeted mutation in a single allele of the thyroid hormone-β receptorReactivation of the silenced thyroid hormone receptor β gene expression delays thyroid tumor progressionNovel functions of thyroid hormone receptor mutants: beyond nucleus-initiated transcription.Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor.Activation of phosphatidylinositol 3-kinase signaling promotes aberrant pituitary growth in a mouse model of thyroid-stimulating hormone-secreting pituitary tumorsNuclear receptor corepressor (NCOR1) regulates in vivo actions of a mutated thyroid hormone receptor αNuclear corepressors mediate the repression of phospholipase A2 group IIa gene transcription by thyroid hormoneDiet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse modelActivation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma.Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms.Novel oncogenic actions of TRbeta mutants in tumorigenesis.Novel non-genomic signaling of thyroid hormone receptors in thyroid carcinogenesis.
P2860
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P2860
An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesis
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@ast
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@en
An unliganded thyroid hormone ...... duces pituitary tumorigenesis.
@nl
type
label
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@ast
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@en
An unliganded thyroid hormone ...... duces pituitary tumorigenesis.
@nl
prefLabel
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@ast
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@en
An unliganded thyroid hormone ...... duces pituitary tumorigenesis.
@nl
P2093
P2860
P1476
An unliganded thyroid hormone ...... nduces pituitary tumorigenesis
@en
P2093
G V R Chandramouli
Hiroko Furumoto
Mark C Willingham
Paul S Meltzer
Robert L Walker
Sheue-Yann Cheng
P2860
P304
P356
10.1128/MCB.25.1.124-135.2005
P407
P577
2005-01-01T00:00:00Z