The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture - Wikidata - thesis-toulmin - TriplyDB

The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

http://www.wikidata.org/entity/Q24632107

about

Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB IRIZIO: a novel gene cooperating with PAX3-FOXO1 in alveolar rhabdomyosarcoma (ARMS)Inhibition of nuclear import by protein kinase B (Akt) regulates the subcellular distribution and activity of the forkhead transcription factor AFX.Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor PAX3-FOXO1 fusion gene in rhabdomyosarcoma PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells Mechanisms of impaired differentiation in rhabdomyosarcoma Inducible short-term and stable long-term cell culture systems reveal that the PAX3-FKHR fusion oncoprotein regulates CXCR4, PAX3, and PAX7 expression Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma Splice variants of the forkhead box protein AFX exhibit dominant negative activity and inhibit AFXalpha-mediated tumor cell apoptosis.FOXOs, cancer and regulation of apoptosis Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).Preclinical experimental therapeutic approaches in soft tissue sarcoma.Pediatric Rhabdomyosarcoma.Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver.An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene Animal models of soft-tissue sarcoma.Gene fusions involving PAX and FOX family members in alveolar rhabdomyosarcoma.Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors.The many forks in FOXO's road.Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts Strong immunostaining for myogenin in rhabdomyosarcoma is significantly associated with tumors of the alveolar subclass.Childhood rhabdomyosarcoma: recent advances and prospective views.Fusion genes resulting from alternative chromosomal translocations are overexpressed by gene-specific mechanisms in alveolar rhabdomyosarcoma.Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein.cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion oncogene.Molecular alterations in pediatric sarcomas: potential targets for immunotherapy Clinical relevance of molecular genetics to paediatric sarcomas Pigmentation PAX-ways: the role of Pax3 in melanogenesis, melanocyte stem cell maintenance, and disease Small molecule inhibition of PAX3-FOXO1 through AKT activation suppresses malignant phenotypes of alveolar rhabdomyosarcoma Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma.High expression of the PAX3-FKHR oncoprotein is required to promote tumorigenesis of human myoblasts Molecular and cellular biology of rhabdomyosarcoma.Caveolins in rhabdomyosarcoma Modeling sarcomagenesis using multipotent mesenchymal stem cells.A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma.

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The hybrid PAX3-FKHR fusion protein of alveolar rhabdomyosarcoma transforms fibroblasts in culture

http://www.wikidata.org/entity/Q24632107

description

1996 nî lūn-bûn

@nan

1996 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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type

label

The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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prefLabel

The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

@ast

The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

@en

The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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PNAS.93.18.9805

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Proceedings of the National Academy of Sciences of the United States of America

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The hybrid PAX3-FKHR fusion pr ...... nsforms fibroblasts in culture

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F G Barr

http://www.w3.org/2001/XMLSchema#string

F J Rauscher

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S Scheidler

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W J Fredericks

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P2860

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia

EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

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18

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14413436

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8790412

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P932

38510

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