Redox-directed cancer therapeutics: molecular mechanisms and opportunities
about
The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosisTowards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examplesUpsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapyThe role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancerGLO1 overexpression in human malignant melanomaA new view of carcinogenesis and an alternative approach to cancer therapyRedox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and TherapyROS and Brain Gliomas: An Overview of Potential and Innovative Therapeutic StrategiesRedox Control of Multidrug Resistance and Its Possible Modulation by AntioxidantsOxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical studentsDisabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant MesotheliomaCrystal structure of human thioredoxin revealing an unraveled helix and exposedS-nitrosation siteDCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinomaMitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cellsHeterogeneous role of the glutathione antioxidant system in modulating the response of ESFT to fenretinide in normoxia and hypoxiaPeroxiredoxin 3 is a redox-dependent target of thiostrepton in malignant mesothelioma cellsMolecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling.Low nanomolar concentrations of Cucurbitacin-I induces G2/M phase arrest and apoptosis by perturbing redox homeostasis in gastric cancer cells in vitro and in vivoCellular and cell-free studies of catalytic DNA cleavage by ruthenium polypyridyl complexes containing redox-active intercalating ligands.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugsThioredoxin-1 inhibitor PX-12 induces human acute myeloid leukemia cell apoptosis and enhances the sensitivity of cells to arsenic trioxideThe small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.Hsp90 is cleaved by reactive oxygen species at a highly conserved N-terminal amino acid motif.Updates of reactive oxygen species in melanoma etiology and progression.Ketogenic diets as an adjuvant cancer therapy: History and potential mechanismA copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo.In vitro CO2-induced ROS production impairs cell cycle in SH-SY5Y neuroblastoma cells.Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.Resveratrol induces premature senescence in lung cancer cells via ROS-mediated DNA damage.The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids.Redox platforms in cancer drug discovery and development.The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death.Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancerThe curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress.Jadomycin breast cancer cytotoxicity is mediated by a copper-dependent, reactive oxygen species-inducing mechanism.The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells.Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis.The extracellular redox state modulates mitochondrial function, gluconeogenesis, and glycogen synthesis in murine hepatocytes.
P2860
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P2860
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@ast
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@en
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@nl
type
label
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@ast
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@en
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@nl
prefLabel
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@ast
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@en
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@nl
P2860
P3181
P356
P1476
Redox-directed cancer therapeutics: molecular mechanisms and opportunities
@en
P2093
Georg T Wondrak
P2860
P304
P3181
P356
10.1089/ARS.2009.2541
P407
P577
2009-12-01T00:00:00Z