Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics
about
Isocyanide-Based Multicomponent Reactions for the Synthesis of HeterocyclesInvestigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of painCurrent research on opioid receptor function.Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitriteExtracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid.Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.Bi- or multifunctional opioid peptide drugs.Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor traffickingSynthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-25'-halogenated analogs of oxymorphindole.Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effectsHeteroatom analogues of hydrocodone: synthesis and biological activityPharmacological traits of delta opioid receptors: pitfalls or opportunities?Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) LigandsMolecular Pharmacology of δ-Opioid Receptors.Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylationModulation between high- and low-frequency transcutaneous electric nerve stimulation delays the development of analgesic tolerance in arthritic rats.Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012).Delta opioid agonists: a concise update on potential therapeutic applications.Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.The design of multitarget ligands for chronic and neuropathic pain.Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS.In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues.Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice.Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.Synthesis and biological evaluation of some novel 1-substituted fentanyl analogs in Swiss albino mice.Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimeraEffects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain.Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy.Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.[6,7]-heterocycle-fused 14-hydroxymorphinan derivatives: design, synthesis, and opioid receptor activity.
P2860
Q26772038-BBBCA17D-CAA0-4C5E-9B28-841ED432913EQ26863769-7ED761E2-163F-49EA-A2D9-FB77F5D68C41Q27693220-98AFD5CA-D1E0-4DE3-B731-50E0064F7197Q30389382-A3FA3255-7522-419A-B817-60A0FC949799Q33325336-97C6F782-328A-4560-A42D-60D6A60535E4Q33662208-4E8746B5-1D60-4D9D-8A82-3A53B21BBDCCQ33767037-18AE49D0-44C7-4AFB-A822-50445FFEEADAQ34538336-7BFF5184-C02A-422C-9054-73BC59735933Q34559481-734EA86D-9F13-4FE5-90C0-DBC5D497C05CQ34989880-34654170-DAE6-4D14-9141-34445D8C7077Q35107996-8643B9CE-0DD5-43E7-B0CD-04806E792CBDQ35184664-9C15821E-A57D-4685-A5B0-21204FAE70C1Q35684498-EA97841A-601E-47CB-A24F-7DEBB9612BBFQ36016398-063146D2-3B04-4578-A6D8-FD5A837D39A3Q36113994-9C6B5753-932B-4AA0-90DF-53992BD9C8DBQ36274635-1DCF7C13-7BC8-4915-B1C2-2E4116F2DC94Q36404602-3E89FA3D-3374-4EC0-BBA7-6DB8AD23D5FDQ36745642-5F4F16D0-739D-44AF-9013-706E5ECBF054Q36920342-825EB786-1055-438F-9FA6-3BD8C9EB1DA2Q36947975-EFB10BC8-D0FB-4C27-BCA3-6913BE52D183Q37062556-5F7CFF64-919A-497C-BE5C-960034401125Q37164022-7FC6B5B2-58A0-474C-A1FE-3408E55E6F84Q37280081-C6546ADD-40CE-4039-B03E-C52FF0A9C4CCQ37347915-F1C5544B-5E6E-4F6A-8418-01CD291BC359Q38109239-B6BABDDD-4D1B-425A-A97D-244414D66CB9Q38366279-B0F5D44E-3C5C-4187-8CE9-9A39D9016F13Q38659429-F6C49C3C-AEF9-4AD5-9F0A-C0193388C484Q38664916-CCE50DEA-7EF7-4E9C-9167-C6496F13F316Q38675489-F132907B-0C48-439D-8964-F4A02621C0BDQ39681968-7CF52105-2D39-4F7B-8937-38E9AE8577A0Q40180659-94F87367-36A8-4904-93AE-5CD2FD60C405Q40269619-8B451BFC-0A91-47E3-BC51-F49289AE0861Q40546885-8E528D85-529A-4B62-9C06-DDFCBAA008CCQ40980675-A60799D2-1973-458E-A139-D83E5F9A31CFQ41411764-65AA4D8C-7442-4646-A1D9-FA137AF9EA98Q41440337-2593A14D-1977-4343-A963-0E5B57C791D9Q41763075-CE1C3FC8-5E59-455C-B529-7603F9356378Q43075643-838DC0B4-0CCF-4D95-A4FA-AE471E940EDBQ43087445-AA3D2637-CA26-46AE-85BC-971C40028962Q43256896-D38DF8F7-23C2-4C33-9498-9F02C4DB242F
P2860
Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics
description
2006 nî lūn-bûn
@nan
2006 թուականին հրատարակուած գիտական յօդուած
@hyw
2006 թվականին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@ast
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@en
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@nl
type
label
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@ast
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@en
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@nl
prefLabel
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@ast
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@en
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@nl
P2860
P356
P1433
P1476
Opioid ligands with mixed mu/d ...... g approach to novel analgesics
@en
P2093
Subramaniam Ananthan
P2860
P2888
P304
P356
10.1208/AAPSJ080114
P407
P577
2006-01-01T00:00:00Z
P5875
P6179
1021393514