14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects
about
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-olsThe mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependenceFurther Optimization and Evaluation of Bioavailable, Mixed-Efficacy μ-Opioid Receptor (MOR) Agonists/δ-Opioid Receptor (DOR) Antagonists: Balancing MOR and DOR Affinities.Opioid peptidomimetics: leads for the design of bioavailable mixed efficacy μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligandsMolecular Pharmacology of δ-Opioid Receptors.Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.Synthesis, modeling, and pharmacological evaluation of UMB 425, a mixed μ agonist/δ antagonist opioid analgesic with reduced tolerance liabilities.Development of functionally selective, small molecule agonists at kappa opioid receptors.Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012).The role of δ-opioid receptors in learning and memory underlying the development of addiction.Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.μ Opioid receptor: novel antagonists and structural modeling.Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.Novel Molecular Strategies and Targets for Opioid Drug Discovery for the Treatment of Chronic Pain.Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.Synthesis and evaluation of 4-substituted piperidines and piperazines as balanced affinity μ opioid receptor (MOR) agonist/δ opioid receptor (DOR) antagonist ligands.Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands.Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics.A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation.
P2860
Q34538336-985B7F52-94FA-43D0-B2AB-D76739023A04Q35142529-12587581-D5BD-4B6E-BDD7-A082E7B05C1BQ36004595-3BDDBD65-8DEE-4508-9164-3188930743FEQ36635468-F8BE7B1A-84EE-443B-9BFD-67F4A1D8EE78Q36745738-4D062A69-1A4E-464A-9F16-7BB845D0D3C9Q37062556-25EC715D-E04D-4246-BA77-9F35C44D66E3Q37160411-D8E001B0-62E4-443A-AF8A-3FA4D3D263C9Q37186178-71A77B66-1CA8-48A2-8327-A90875F160F4Q37405071-9586B04B-8A36-43AC-9CAA-0FAC9D9A0622Q38109239-30FD442A-AF8E-43A1-B457-C9C579D65B7FQ38196926-EA2023C8-4068-459E-B473-0423898ABF61Q38395503-F5478BE4-4D23-4521-B887-54A402BE5514Q38541351-DCFD41B6-A9BA-4161-8CBE-FAFFABA84695Q38659429-F815DBD1-0DEA-447D-A045-9E00554C9968Q38690048-3EC90D78-BDDC-4FEB-8B9A-D00537D8E52EQ39157737-968A6FDA-7DAE-4A62-BA57-83F13A4986FAQ40980675-8921BCF7-5C9B-464D-9BB9-7DD2F2211689Q41768815-216ABE74-010E-4E40-833B-18746B45F84CQ44342205-E1499750-7F87-4CB7-9F4A-CE8977D799D4Q44351142-2F314B51-BCC8-4FE8-BA20-6DBAC7EA13D4Q50218322-9A4D271E-6067-415F-BC65-70AE37116EB1
P2860
14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@ast
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@en
type
label
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@ast
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@en
prefLabel
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@ast
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@en
P2093
P2860
P356
P1476
14-Alkoxy- and 14-acyloxypyrid ...... ce and dependence side effects
@en
P2093
Christina M Dersch
Denise Giuvelis
Nicholas McGlinchey
Richard B Rothman
Subramaniam Ananthan
Surendra K Saini
P2860
P304
P356
10.1021/JM300686P
P407
P577
2012-09-27T00:00:00Z