Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes - Wikidata - thesis-toulmin - TriplyDB

Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

http://www.wikidata.org/entity/Q24651549

about

Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization Development of humanized mouse models to study human malaria parasite infection Designing the next generation of medicines for malaria control and eradication Linking Murine and Human Plasmodium falciparum Challenge Models in a Translational Path for Antimalarial Drug Development.Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential Antimalarial drug discovery - approaches and progress towards new medicines.A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria Diversity-oriented synthesis yields novel multistage antimalarial inhibitors New developments in anti-malarial target candidate and product profiles Further improvements of the P. falciparum humanized mouse model A new in vivo screening paradigm to accelerate antimalarial drug discovery Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum.A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue Natural products as starting points for future anti-malarial therapies: going back to our roots?Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds Current advances in humanized mouse models.Cyclopropyl Carboxamides: A New Oral Antimalarial Series Derived from the Tres Cantos Anti-Malarial Set (TCAMS).Repositioning: the fast track to new anti-malarial medicines?A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.Humanized mouse models to study human diseases Analysis of innate defences against Plasmodium falciparum in immunodeficient mice.Generation of improved humanized mouse models for human infectious diseases.Quinolone-3-diarylethers: a new class of antimalarial drug.Immortalization of erythroblasts by c-MYC and BCL-XL enables large-scale erythrocyte production from human pluripotent stem cells Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1 Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans Cyclopropyl carboxamides, a chemically novel class of antimalarial agents identified in a phenotypic screen.De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection.Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice.New molecular settings to support in vivo anti-malarial assays.Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials.

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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

http://www.wikidata.org/entity/Q24651549

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Antimicrobial Agents and Chemotherapy

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Angela Alvarez-Doval

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Antonio Martínez

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Domingo Gargallo-Viola

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Helen Garuti

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Javier Ibáñez

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Leonard D Shultz

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María Belén Jiménez-Díaz

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Sara Viera

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Teresa Mulet

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Vanessa Gómez

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P2860

Malaria: progress, perils, and prospects for eradication

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria.

Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

Humanized mice in translational biomedical research.

Selection of a trioxaquine as an antimalarial drug candidate.

Humanized SCID mouse models for biomedical research.

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.

Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence.

The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates.

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711273

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10.1128/AAC.00519-09

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10

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53

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Iñigo Angulo-Barturen

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19596869

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Plasmodium falciparum

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2764183

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