A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria
about
sameAs
Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate DehydrogenaseEfficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents.Humanized mouse models infected with human Plasmodium species for antimalarial drug discovery.Enhanced ex vivo Plasmodium vivax intraerythrocytic enrichment and maturation for rapid and sensitive parasite growth assays.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of MalariaAntimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a studyMalariaIsoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity
P2860
Q30041606-8C0E4B3F-0230-45D9-9A31-DACDFFC75B70Q40043829-7A809E6C-1496-467B-9784-977A93D584C6Q41992966-EFE7DE89-E7FA-4DA6-9D34-5B1CB6B69847Q46252657-82E08DC1-5E72-4850-9EED-8E31535FA0E1Q48023790-41228550-3B70-48BE-8517-AF5533FAA00AQ49927350-8CEC9FE8-76CF-47FA-AF9D-91927E9F4A72Q56340021-A97C5582-5F84-4C15-8688-315B1FD1F078Q56352603-FF32904C-8E45-4C40-BBFF-F2960073D1ADQ56378965-AD646AFA-4D0C-4336-B27D-96F09D25A835Q58776522-940E6D8A-BBE2-4DA8-B1C8-C9D399A98FDB
P2860
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria
description
2016 nî lūn-bûn
@nan
2016 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@ast
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@en
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor
@nl
type
label
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@ast
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@en
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor
@nl
altLabel
A Triazolopyrimidine-Based Dih ...... ment and Prevention of Malaria
@en
prefLabel
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@ast
A triazolopyrimidine-based dih ...... ment and prevention of malaria
@en
A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor
@nl
P2093
P2860
P50
P1476
A Triazolopyrimidine-Based Dih ...... ment and Prevention of Malaria
@en
P2093
Benjamin Blasco
Dave Matthews
David M Shackleford
David Waterson
Didier Leroy
Farah El Mazouni
Francis C K Chiu
John White
Kakali Rani Rudra
Karen L White
P2860
P304
P356
10.1021/ACSINFECDIS.6B00144
P407
P50
P577
2016-12-09T00:00:00Z