Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
about
JDP2 (Jun Dimerization Protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescenceThe ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesisJdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosityAntisense transcription in gammaretroviruses as a mechanism of insertional activation of host genesThe AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in miceTRE-dependent transcription activation by JDP2-CHOP10 associationDosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 functionRas inhibition boosts galectin-7 at the expense of galectin-1 to sensitize cells to apoptosisSuppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2Phosphorylation of JDP2 on threonine-148 by the c-Jun N-terminal kinase targets it for proteosomal degradationCancer gene discovery in mouse and man.Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motilityInsertional mutagenesis and deep profiling reveals gene hierarchies and a Myc/p53-dependent bottleneck in lymphomagenesis.Runx2 mediates epigenetic silencing of the bone morphogenetic protein-3B (BMP-3B/GDF10) in lung cancer cells.Role of Runx2 phosphorylation in prostate cancer and association with metastatic disease.The RUNX Genes as Conditional Oncogenes: Insights from Retroviral Targeting and Mouse Models.Host JDP2 expression in the bone marrow contributes to metastatic spreadLarge-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.Insertional oncogenesis by non-acute retroviruses: implications for gene therapy.Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.
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P2860
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@ast
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@en
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@nl
type
label
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@ast
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@en
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@nl
prefLabel
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@ast
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@en
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@nl
P2093
P2860
P1433
P1476
Insertional mutagenesis reveals progression genes and checkpoints in MYC/Runx2 lymphomas
@en
P2093
Ewan Cameron
James C Neil
Linda Hanlon
Linda Scobie
Monica Stewart
Nancy Mackay
P2860
P304
P356
10.1158/0008-5472.CAN-07-0433
P407
P50
P577
2007-06-01T00:00:00Z