Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta - Wikidata - thesis-toulmin - TriplyDB

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

http://www.wikidata.org/entity/Q24669877

about

Piceatannol, natural polyphenolic stilbene, inhibits adipogenesis via modulation of mitotic clonal expansion and insulin receptor-dependent insulin signaling in early phase of differentiation Therapeutic Implications of Targeting AKT Signaling in Melanoma Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3 Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies Akt1 in endothelial cell and angiogenesis Connecting Myokines and Metabolism Involvement of protein tyrosine phosphatases in adipogenesis: new anti-obesity targets?Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies Akt isoforms in vascular disease PI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasms mTOR-dependent cell survival mechanisms Targeting oncogenic ALK and MET: a promising therapeutic strategy for glioblastoma Posttranslational regulation of Akt in human cancer Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways mTOR signaling in tumorigenesis PI3K/PTEN signaling in angiogenesis and tumorigenesis Role for Akt3/protein kinase Bgamma in attainment of normal brain size Insulin-modulated Akt subcellular localization determines Akt isoform-specific signaling.Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts Enhanced rat beta-cell proliferation in 60% pancreatectomized islets by increased glucose metabolic flux through pyruvate carboxylase pathway Aging and the Mammalian regulatory triumvirate Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition Biological Chemistry and Functionality of Protein Sulfenic Acids and Related Thiol Modifications Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases Macrophage plasticity and polarization: in vivo veritas All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.Disassociation of insulin action and Akt/FOXO signaling in skeletal muscle of older Akt-deficient mice.Akt3 is responsible for the survival and proliferation of embryonic stem cells Akt isoforms differentially regulate neutrophil functions Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling.Brown adipose tissue mapping in rats with combined intermolecular double-quantum coherence and Dixon water-fat MRI.Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1 Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).Deletion of PKBalpha/Akt1 affects thymic development Akt1 in osteoblasts and osteoclasts controls bone remodeling.Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia.Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass.11β-HSD1 modulates LPS-induced innate immune responses in adipocytes by altering expression of PTEN.

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Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

http://www.wikidata.org/entity/Q24669877

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

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Journal of Clinical Investigation

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Severe diabetes, age-dependent ...... in mice lacking Akt2/PKB beta

@en

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Anthony J Torchia

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Audrey L Hildebrandt

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Dominique J Brees

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Jeffrey L Stock

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Joan R Wicks

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John D McNeish

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Kevin G Coleman

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Kristina Rafidi

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Robert S Garofalo

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Shawn C Black

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P2860

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Disruption of IRS-2 causes type 2 diabetes in mice

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

The PI3K-PDK1 connection: more than just a road to PKB

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

CEACAM1 regulates insulin clearance in liver

Akt signaling: linking membrane events to life and death decisions

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197-208

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scholarly article

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1292021

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10.1172/JCI16885

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2

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112

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2003-07-01T00:00:00Z

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10676835

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12843127

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164287

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