Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance - Wikidata - thesis-toulmin - TriplyDB

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

http://www.wikidata.org/entity/Q27650096

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AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR Ubiquitin-specific protease 4 inhibits mono-ubiquitination of the master growth factor signaling kinase PDK1 Requirement of 3-phosphoinositide-dependent protein kinase-1 for BDNF-mediated neuronal survival Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis Targeting SGK1 in diabetes A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening.The physiological impact of the serum and glucocorticoid-inducible kinase SGK1 PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development.Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.The kinase PDK1 is essential for B-cell receptor mediated survival signaling.Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.Multiple implications of 3-phosphoinositide-dependent protein kinase 1 in human cancer.Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains.miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.Phosphatidylserine binding is essential for plasma membrane recruitment and signaling function of 3-phosphoinositide-dependent kinase-1.Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.Phosphoinositide-dependent kinase-1 and protein kinase Cδ contribute to endothelin-1 constriction and elevated blood pressure in intermittent hypoxia Phosphatidylinositol-3,4,5-triphosphate and cellular signaling: implications for obesity and diabetes.Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability.Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)Cross talk between the Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling.3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.New insights into the regulation and function of serine/threonine kinases in T lymphocytes.Hepatic gluconeogenesis is enhanced by phosphatidic acid which remains uninhibited by insulin in lipodystrophic Agpat2-/- mice.Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration Akt isoforms and glucose homeostasis - the leptin connection.Metabolism, migration and memory in cytotoxic T cells.The coordination of T-cell function by serine/threonine kinases.Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases.Serine-threonine kinases in TCR signaling.Transcription factors and cognate signalling cascades in the regulation of autophagy.

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Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

http://www.wikidata.org/entity/Q27650096

description

2008 nî lūn-bûn

@nan

2008 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2008年の論文

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2008年論文

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2008年論文

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2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

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2008年论文

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name

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@ast

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@en

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

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type

label

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@ast

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@en

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@nl

prefLabel

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@ast

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@en

Mutation of the PDK1 PH Domain ...... ll Size and Insulin Resistance

@nl

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Molecular and Cellular Biology

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Mutation of the PDK1 PH domain ...... ll size and insulin resistance

@en

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Carol Clacher

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David Komander

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Florian Lang

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Janna A van Diepen

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John A Chudek

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Juan M García-Martínez

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Kei Sakamoto

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Krishna M Boini

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Peter J Voshol

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Stephan Wullschleger

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P2860

PDK1, the master regulator of AGC kinase signal transduction

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Essential role of PDK1 in regulating cell size and development in mice

Identification of a pocket in the PDK1 kinase domain that interacts with PIF and the C-terminal residues of PKA

S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies

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3258-3272

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scholarly article

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10.1128/MCB.02032-07

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10

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28

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Calum Sutherland

Jose R. Bayascas

Daan van Aalten

Christopher Lipina

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2008-03-17T00:00:00Z

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5505533

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18347057

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2423167

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