75 years of opioid research: the exciting but vain quest for the Holy Grail
about
Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependenceCholinergic modulation by opioid receptor ligands: potential application to Alzheimer's diseasePositive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medicationsStructural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signalingThe mGluR5 antagonist fenobam induces analgesic conditioned place preference in mice with spared nerve injuryOpioid-induced decreases in rat brain adenosine levels are reversed by inhibiting adenosine deaminaseGenetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS)Salvinorin A analogs as probes in opioid pharmacology.Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the EndorphinsConformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.Development and validation of a UPLC-MS/MS method for the determination of 7-hydroxymitragynine, a μ-opioid agonist, in rat plasma and its application to a pharmacokinetic study.The effects of opioids and opioid analogs on animal and human endocrine systemsNicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin.Functional impact of a single-nucleotide polymorphism in the OPRD1 promoter region.Evaluation of the agonist PET radioligand [¹¹C]GR103545 to image kappa opioid receptor in humans: kinetic model selection, test-retest reproducibility and receptor occupancy by the antagonist PF-04455242.Operant nociception in nonhuman primates.Morphine regulates dopaminergic neuron differentiation via miR-133b.μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro.Opioids and the treatment of chronic pain: controversies, current status, and future directions.Cellular signalling of non-synonymous single-nucleotide polymorphisms of the human μ-opioid receptor (OPRM1)Regulation of κ-opioid receptor signaling in peripheral sensory neurons in vitro and in vivo.Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats.Neuropsychological Functions of μ- and δ-Opioid Systems.MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys.Engineering endomorphin drugs: state of the art.Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.Tolerance to the antinociceptive effects of chronic morphine requires c-Jun N-terminal kinase.Rare diseases and orphan drugs.Pharmacology of nonsteroidal antiinflammatory drugs and opioidsActivation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea.Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivoEndomorphin-2: a biased agonist at the μ-opioid receptor.The endogenous opioid system in cocaine addiction: what lessons have opioid peptide and receptor knockout mice taught us?Morphine and microRNA Activity: Is There a Relation with Addiction?Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.In vivo regulation of the μ opioid receptor: role of the endogenous opioid agents.Tolerance to the antinociceptive and hypothermic effects of morphine is mediated by multiple isoforms of c-Jun N-terminal kinase.Neoclerodanes as atypical opioid receptor ligands
P2860
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P2860
75 years of opioid research: the exciting but vain quest for the Holy Grail
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
name
75 years of opioid research: the exciting but vain quest for the Holy Grail
@ast
75 years of opioid research: the exciting but vain quest for the Holy Grail
@en
75 years of opioid research: the exciting but vain quest for the Holy Grail
@nl
type
label
75 years of opioid research: the exciting but vain quest for the Holy Grail
@ast
75 years of opioid research: the exciting but vain quest for the Holy Grail
@en
75 years of opioid research: the exciting but vain quest for the Holy Grail
@nl
prefLabel
75 years of opioid research: the exciting but vain quest for the Holy Grail
@ast
75 years of opioid research: the exciting but vain quest for the Holy Grail
@en
75 years of opioid research: the exciting but vain quest for the Holy Grail
@nl
P2093
P2860
P3181
P356
P1476
75 years of opioid research: the exciting but vain quest for the Holy Grail
@en
P2093
Alexander T McKnight
Alistair D Corbett
Graeme Henderson
Stewart J Paterson
P2860
P304
P3181
P356
10.1038/SJ.BJP.0706435
P407
P478
147 Suppl 1
P577
2006-01-01T00:00:00Z