Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism - Wikidata - thesis-toulmin - TriplyDB

Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

http://www.wikidata.org/entity/Q24672755

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Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate Structural basis for induced formation of the inflammatory mediator prostaglandin E2.GSTCD and INTS12 regulation and expression in the human lung Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis Arginine 104 Is a Key Catalytic Residue in Leukotriene C4 Synthase The Catalytic Architecture of Leukotriene C4 Synthase with Two Arginine Residues Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy Effect of Vitamin E on Glutathione-Dependent Enzymes Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily The leukotriene C(4) synthase gene and asthma (S)-preferential detoxification of 4-hydroxy-2(E)-nonenal enantiomers by hepatic glutathione S-transferase isoforms in guinea-pigs and rats Structure and inhibition of mouse leukotriene C4 synthase Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells Global Kinetic Mechanism of Microsomal Glutathione Transferase 1, insights into dynamic enzyme activation.Large-scale determination of previously unsolved protein structures using evolutionary information Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis.Mu-class glutathione transferase from Xenopus laevis: molecular cloning, expression and site-directed mutagenesis The Incomplete Glutathione Puzzle: Just Guessing at Numbers and Figures?Absence of MGST1 mRNA and protein expression in human neuroblastoma cell lines and primary tissue.Biomarkers of mercury exposure in the Amazon The transcriptional network of WRKY53 in cereals links oxidative responses to biotic and abiotic stress inputs Human glutathione dependent prostaglandin E synthase: gene structure and regulation.Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress.Location, location, location: compartmentalization of early events in leukotriene biosynthesis.Glutathione transferases: a structural perspective.Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging.Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione.Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells.The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution.Glutathione transferases in bacteria.Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1)Large-scale determination of sequence, structure, and function relationships in cytosolic glutathione transferases across the biosphere.Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species.Glutathione S-Transferase (GST) Gene Diversity in the Crustacean Calanus finmarchicus--Contributors to Cellular Detoxification.The role of glutathione in intestinal dysfunction.

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Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism

http://www.wikidata.org/entity/Q24672755

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1999 nî lūn-bûn

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A Ford-Hutchinson

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B Persson

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J Mancini

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P2860

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities

Production of leukotriene C4 in different human tissues is attributable to distinct membrane bound biosynthetic enzymes

Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase

A model for p53-induced apoptosis

5-lipoxygenase-activating protein is an arachidonate binding protein

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits

Molecular cloning and expression of human leukotriene-C4 synthase

Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4

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