Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
about
The transcription factor p53: not a repressor, solely an activatorCalcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cellsSAK, a new polo-like kinase, is transcriptionally repressed by p53 and induces apoptosis upon RNAi silencingHuman enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosisMutant p53 Drives Cancer by Subverting Multiple Tumor Suppression PathwaysPutting a bit into the polo-box domain of polo-like kinase 1Polo Like Kinase 2 Tumour Suppressor and cancer biomarker: new perspectives on drug sensitivity/resistance in ovarian cancerStructural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1Serendipitous alkylation of a Plk1 ligand uncovers a new binding channelSelective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brainDNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosisDesign and synthesis of a cell-permeable, drug-like small molecule inhibitor targeting the polo-box domain of polo-like kinase 1Polo-like kinases and the orchestration of cell divisionUncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.NGF-mediated transcriptional targets of p53 in PC12 neuronal differentiation.Phosphorylation of p21 in G2/M promotes cyclin B-Cdc2 kinase activity.Mutant TP53 posttranslational modifications: challenges and opportunities.BUB3 that dissociates from BUB1 activates caspase-independent mitotic death (CIMD).Polo-box domain: a versatile mediator of polo-like kinase function.MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2 in laryngeal carcinomaThe p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.Hormonal induction of polo-like kinases (Plks) and impact of Plk2 on cell cycle progression in the rat ovary.Profiles of global gene expression in ionizing-radiation-damaged human diploid fibroblasts reveal synchronization behind the G1 checkpoint in a G0-like state of quiescence.Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.Polo-like kinases (plks), a key regulator of cell cycle and new potential target for cancer therapy.Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposure.Transgenic and knockout mice models to reveal the functions of tumor suppressor genes.T-cell activation and early gene response in dogs.Identification of the PLK2-dependent phosphopeptidome by quantitative proteomics [corrected].The role of p53 in chemosensitivity and radiosensitivity.Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer TreatmentDiscovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).The isolation of an RNA aptamer targeting to p53 protein with single amino acid mutation.Identification of gene markers for formaldehyde exposure in humans.BUB1 mediation of caspase-independent mitotic death determines cell fate.MicroRNA-146a Induces Lineage-Negative Bone Marrow Cell Apoptosis and Senescence by Targeting Polo-Like Kinase 2 Expression.Recent Advances and New Strategies in Targeting Plk1 for Anticancer TherapyPLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cells
P2860
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P2860
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@ast
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@en
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@nl
type
label
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@ast
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@en
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@nl
prefLabel
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@ast
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@en
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@nl
P2093
P2860
P921
P1476
Silencing of the novel p53 tar ...... clitaxel (taxol)-exposed cells
@en
P2093
David T Dicker
Kimberly A Scata
Peiwen Fei
Timothy F Burns
P2860
P304
P356
10.1128/MCB.23.16.5556-5571.2003
P407
P577
2003-08-01T00:00:00Z