A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
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The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tetheringVirological and cellular roles of the transcriptional coactivator LEDGF/p75Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationImpact of Chromatin on HIV Replicationp12 tethers the murine leukemia virus pre-integration complex to mitotic chromosomesAllosteric Inhibition of Human Immunodeficiency Virus IntegraseA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomesNucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domainMultimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase InhibitorsMultiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motifLEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactorsThe Gag cleavage product, p12, is a functional constituent of the murine leukemia virus pre-integration complexNon-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cellsNuclear protein LEDGF/p75 recognizes supercoiled DNA by a novel DNA-binding domainHepatoma-derived growth factor-related protein-3 interacts with microtubules and promotes neurite outgrowth in mouse cortical neuronsRetroviral DNA IntegrationHIV/AIDS epidemiology, pathogenesis, prevention, and treatmentLEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivityDifferential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integrationHRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Identification and functional analysis of NOL7 nuclear and nucleolar localization signals.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.SUMOylation of the lens epithelium-derived growth factor/p75 attenuates its transcriptional activity on the heat shock protein 27 promoter.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINsMolecular mechanisms of retroviral integration site selection.Understanding lentiviral vector chromatin targeting: working to reduce insertional mutagenic potential for gene therapy.Retroviral integrase proteins and HIV-1 DNA integrationDisruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformationsRepair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.Identification and characterization of nuclear and nucleolar localization signals in 58-kDa microspherule protein (MSP58)DNA Physical Properties and Nucleosome Positions Are Major Determinants of HIV-1 Integrase SelectivityTranscriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration.Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting
P2860
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P2860
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
description
2006 nî lūn-bûn
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2006 թուականին հրատարակուած գիտական յօդուած
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2006 թվականին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@ast
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@en
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@nl
type
label
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@ast
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@en
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@nl
prefLabel
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@ast
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@en
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@nl
P2093
P2860
P3181
P356
P1476
A tripartite DNA-binding eleme ...... DGF/p75 with chromatin in vivo
@en
P2093
Alan Engelman
Fanny Turlure
Goedele Maertens
Shaila Rahman
P2860
P304
P3181
P356
10.1093/NAR/GKL052
P407
P577
2006-01-01T00:00:00Z