about
LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cellsRetroviral intasome assembly and inhibition of DNA strand transferTranscriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activityLEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integrationA tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivoStructural basis for functional tetramerization of lentiviral integraseFunctional and structural characterization of the integrase from the prototype foamy virusA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75The mechanism of retroviral integration from X-ray structures of its key intermediatesStructural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)Activities, Crystal Structures, and Molecular Dynamics of Dihydro-1 H -isoindole Derivatives, Inhibitors of HIV-1 IntegraseStructural basis for nuclear import of splicing factors by human Transportin 3Crystal structure of human CDC7 kinase in complex with its activator DBF4HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Peter Cherepanov
@ast
Peter Cherepanov
@en
Peter Cherepanov
@es
Peter Cherepanov
@nl
Peter Cherepanov
@sl
type
label
Peter Cherepanov
@ast
Peter Cherepanov
@en
Peter Cherepanov
@es
Peter Cherepanov
@nl
Peter Cherepanov
@sl
prefLabel
Peter Cherepanov
@ast
Peter Cherepanov
@en
Peter Cherepanov
@es
Peter Cherepanov
@nl
Peter Cherepanov
@sl