Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration
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Synaptic function of nicastrin in hippocampal neuronsInactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunctionProteolytic processing of Alzheimer's β-amyloid precursor proteinPartial loss of presenilin impairs age-dependent neuronal survival in the cerebral cortexDeletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementiaAdipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity.CREB binding protein is required for both short-term and long-term memory formation.Loss of Nicastrin from Oligodendrocytes Results in Hypomyelination and Schizophrenia with Compulsive Behavior.Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice.Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.An overview of APP processing enzymes and products.Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged miceThe γ-secretase complex: from structure to function.Targets for AD treatment: conflicting messages from γ-secretase inhibitorsPresenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease.An overview of notch signaling in adult tissue renewal and maintenance.Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels.Minocycline reduces neuroinflammation but does not ameliorate neuron loss in a mouse model of neurodegenerationConditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteinsThe endocannabinoid, anandamide, augments Notch-1 signaling in cultured cortical neurons exposed to amyloid-β and in the cortex of aged ratsA novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain.Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.Amyloid-independent mechanisms in Alzheimer's disease pathogenesisPresenilins in synaptic function and disease.Function and dysfunction of presenilinInterpreting Alzheimer's disease clinical trials in light of the effects on amyloid-β.Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases.Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration.Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain.Conditional Deletion of PDK1 in the Forebrain Causes Neuron Loss and Increased Apoptosis during Cortical Development.Increased adult neurogenesis associated with reactive astrocytosis occurs prior to neuron loss in a mouse model of neurodegenerative disease.γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor.The genes associated with early-onset Alzheimer's disease.
P2860
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P2860
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration
description
2009 nî lūn-bûn
@nan
2009 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Conditional forebrain inactiva ...... age-related neurodegeneration
@ast
Conditional forebrain inactiva ...... age-related neurodegeneration
@en
Conditional forebrain inactiva ...... age-related neurodegeneration
@nl
type
label
Conditional forebrain inactiva ...... age-related neurodegeneration
@ast
Conditional forebrain inactiva ...... age-related neurodegeneration
@en
Conditional forebrain inactiva ...... age-related neurodegeneration
@nl
prefLabel
Conditional forebrain inactiva ...... age-related neurodegeneration
@ast
Conditional forebrain inactiva ...... age-related neurodegeneration
@en
Conditional forebrain inactiva ...... age-related neurodegeneration
@nl
P2093
P2860
P3181
P1476
Conditional forebrain inactiva ...... age-related neurodegeneration
@en
P2093
Guiquan Chen
Katsuhiko Tabuchi
P2860
P304
P3181
P356
10.1523/JNEUROSCI.1320-09.2009
P407
P577
2009-06-03T00:00:00Z