Structure and pharmacology of pentameric receptor channels: from bacteria to brain
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Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogasterAnesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptorsThe concept of allosteric interaction and its consequences for the chemistry of the brainThe nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamilyPathways and Barriers for Ion Translocation through the 5-HT3A Receptor ChannelStructural basis for ion permeation mechanism in pentameric ligand-gated ion channelsCrystal structures of a pentameric ligand-gated ion channel provide a mechanism for activationStructural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding proteinA predicted binding site for cholesterol on the GABAA receptorFunctional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing groundCrosslinking constraints and computational models as complementary tools in modeling the extracellular domain of the glycine receptorIdentification and functional expression of a glutamate- and avermectin-gated chloride channel from Caligus rogercresseyi, a southern Hemisphere sea louse affecting farmed fishMutations at beta N265 in γ-aminobutyric acid type A receptors alter both binding affinity and efficacy of potent anestheticsIn vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic toolPhotoaffinity Labeling of Pentameric Ligand-Gated Ion Channels: A Proteomic Approach to Identify Allosteric Modulator Binding Sites.X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors.CHEXVIS: a tool for molecular channel extraction and visualizationIdentification of a pre-active conformation of a pentameric channel receptorELIC-α7 Nicotinic acetylcholine receptor (α7nAChR) chimeras reveal a prominent role of the extracellular-transmembrane domain interface in allosteric modulation.An internally modulated, thermostable, pH-sensitive Cys loop receptor from the hydrothermal vent worm Alvinella pompejanaCalcium signalling and calcium channels: evolution and general principles.Moving Fe2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates.Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranesEvolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Evidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit.Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencingAllosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structurePoly(ethylene glycol) as a scaffold for high-affinity open-channel blockers of the mouse nicotinic acetylcholine receptor.Allosteric regulation of pentameric ligand-gated ion channels: an emerging mechanistic perspectiveFunctional anatomy of an allosteric protein.Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion ChannelIdentification and Characterization of a G Protein-binding Cluster in α7 Nicotinic Acetylcholine ReceptorsA chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation.Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.Binding interactions with the complementary subunit of nicotinic receptors.
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P2860
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
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2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@ast
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@en
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@nl
type
label
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@ast
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@en
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@nl
prefLabel
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@ast
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@en
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@nl
P2093
P50
P3181
P1433
P1476
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
@en
P2093
Frédéric Poitevin
Ludovic Sauguet
Marie S. Prevost
P304
P3181
P356
10.1016/J.STR.2012.05.003
P407
P577
2012-06-06T00:00:00Z