Pregnane X receptor as a target for treatment of inflammatory bowel disorders - Wikidata - thesis-toulmin - TriplyDB

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

http://www.wikidata.org/entity/Q26998347

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Role of pregnane X receptor in chemotherapeutic treatment Targeting xenobiotic receptors PXR and CAR in human diseases Brain-gut microbiome interactions and functional bowel disorders The Concise Guide to PHARMACOLOGY 2013/14: nuclear hormone receptors.Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation Attenuation of Innate Immunity by Andrographolide Derivatives Through NF-κB Signaling Pathway.Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate.Notoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activation Pregnane X receptor modulates the inflammatory response in primary cultures of hepatocytes Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.Review article: potential mechanisms of action of rifaximin in the management of irritable bowel syndrome with diarrhoea.Small-molecule modulators of PXR and CAR.SUMOylation and Ubiquitylation Circuitry Controls Pregnane X Receptor Biology in Hepatocytes.Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice PXR antagonists and implication in drug metabolism.Pleiotropic roles of bile acids in metabolism.PXR ablation alleviates diet-induced and genetic obesity and insulin resistance in mice.Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.Epigenetic regulation of pregnane X receptor activity.Bile acid receptors as targets for drug development.Rifaximin: beyond the traditional antibiotic activity.Bile acid malabsorption in inflammatory bowel disease.Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.A SUMO-acetyl switch in PXR biology.Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells.Functions of pregnane X receptor in self-detoxification.Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation.Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health.Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway.Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor.High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.The Molecular Interface Between the SUMO and Ubiquitin Systems.Role of Toll-like receptor 4 in drug-drug interaction between paclitaxel and irinotecan in vitro.

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

http://www.wikidata.org/entity/Q26998347

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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

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Trends in Pharmacological Sciences

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Pregnane X receptor as a target for treatment of inflammatory bowel disorders

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Frank J. Gonzalez

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Jie Cheng

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Yatrik M. Shah

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P2860

Structure of an IkappaBalpha/NF-kappaB complex

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

Activation of innate immune antiviral responses by Nod2

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Genetics and pathogenesis of inflammatory bowel disease

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10.1016/J.TIPS.2012.03.003

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inflammatory bowel diseases

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