about
Reverse yeast two-hybrid system to identify mammalian nuclear receptor residues that interact with ligands and/or antagonistsExploration of the conformational landscape in pregnane X receptor reveals a new binding pocketPlant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway.Pregnane X receptor and drug-induced liver injury.Nonalcoholic Fatty liver disease: pathogenesis and therapeutics from a mitochondria-centric perspective.Zebrafish as model organisms for studying drug-induced liver injuryNotoginsenoside R1 attenuates experimental inflammatory bowel disease via pregnane X receptor activationStatins Increase Plasminogen Activator Inhibitor Type 1 Gene Transcription through a Pregnane X Receptor Regulated Element.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoSmall-molecule modulators of PXR and CAR.Diindolylmethane, a naturally occurring compound, induces CYP3A4 and MDR1 gene expression by activating human PXR.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.A concentration addition model to assess activation of the pregnane X receptor (PXR) by pesticide mixtures found in the French diet.Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXRTumor suppressor protein p53 negatively regulates human pregnane X receptor activity.Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.Pregnane X Receptor and Cancer: Context-Specificity is Key.Ligand promiscuity of aryl hydrocarbon receptor agonists and antagonists revealed by site-directed mutagenesis.Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB PathwayAcetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity.SPA70 is a potent antagonist of human pregnane X receptor.Genetic variations of the xenoreceptors NR1I2 and NR1I3 and their effect on drug disposition and response variability.High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
PXR antagonists and implication in drug metabolism.
@ast
PXR antagonists and implication in drug metabolism.
@en
type
label
PXR antagonists and implication in drug metabolism.
@ast
PXR antagonists and implication in drug metabolism.
@en
prefLabel
PXR antagonists and implication in drug metabolism.
@ast
PXR antagonists and implication in drug metabolism.
@en
P2860
P1476
PXR antagonists and implication in drug metabolism.
@en
P2093
P2860
P356
10.3109/03602532.2012.746363
P407
P577
2013-02-01T00:00:00Z