Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice
about
Experimental neurotransplantation treatment for hereditary cerebellar ataxiasAnxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease.Spinocerebellar ataxia in the Italian Spinone dog is associated with an intronic GAA repeat expansion in ITPR1Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.Evaluation of Antisense Oligonucleotides Targeting ATXN3 in SCA3 Mouse ModelsOligonucleotide-based strategies to combat polyglutamine diseases.RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph diseaseTransplantation and Stem Cell Therapy for Cerebellar Degenerations.Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia.Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23Nonallele specific silencing of ataxin-7 improves disease phenotypes in a mouse model of SCA7.Fibroblasts of Machado Joseph Disease patients reveal autophagy impairment.Toward RNAi therapy for the polyglutamine disease Machado-Joseph diseaseDisease-causing allele-specific silencing by RNA interference.Antisense gene silencing: therapy for neurodegenerative disorders?Ataxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.Allele-selective suppression of mutant genes in polyglutamine diseases.From mice to men: lessons from mutant ataxic mice.Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Current concepts in the treatment of hereditary ataxias.Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.Knockdown and replacement therapy mediated by artificial mirtrons in spinocerebellar ataxia 7.Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 MiceThe Expression of Tubb2b Undergoes a Developmental Transition in Murine Cortical Neurons.Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.Treatment of Spinocerebellar Ataxia With Mesenchymal Stem Cells: A Phase I/IIa Clinical Study.Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3.Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia.Allele-specific silencing therapy for Dynamin 2-related dominant centronuclear myopathy.Human Umbilical Cord Mesenchymal Stem Cells Protect Against SCA3 by Modulating the Level of 70 kD Heat Shock Protein.RNAi-mediated knockdown of IKK1 in transgenic mice using a transgenic construct containing the human H1 promoter.
P2860
Q26752137-DB6BC36A-64DC-42A6-A067-FC7FCAC4CE3AQ30438962-B089238D-3DB6-4CC5-9EAC-530DB15D2D09Q30618025-4992DBDD-A0F6-47ED-86BA-6BB322A0D253Q30703360-30D829E8-287C-40F2-A6EF-2B5E87262463Q33635375-AD19DF96-1927-4F5E-AF44-08CFC3BADEB1Q33791247-3FB83E8C-45A1-4936-AF13-7EFADCA25C09Q34075342-51EC4117-FC14-4EBC-AE62-F961364B192AQ34484111-E8383BD3-87B8-499B-BC95-5B63BE844062Q34499502-884A0F80-F9DA-477B-8BD5-80C451BA2AAFQ34541372-84412DDC-74A5-4EF8-980A-6C8E22655AE3Q35618581-120FE8F0-1146-4E17-9016-0780089DB88BQ37027391-02A1C75A-67F2-4596-997E-E3BBB719C588Q37254846-A0FA46F5-B12C-40FB-83BB-275D3EA18337Q37277394-5BAC5067-DDC2-42D7-AB6C-551D0A2FA61FQ37585001-A7223C98-5187-4803-83DD-1ADC6A19BAB7Q38167681-F98A02A7-0C9F-4F95-AECB-28DCD256806AQ38547027-2DD0E9E3-F5B1-4965-93AC-9BC12B025257Q38578808-B9D8A3CA-D106-4587-A6B9-24C579CF8409Q38714908-54164FBA-B3C5-4A95-9DF8-710D4460B7EDQ38792714-F6309815-3DA0-47CE-90A3-190E5FD85D4EQ38799644-9B082AB8-48E7-41C6-BCAE-8C2D0ADF4BC9Q40906363-DA226689-2868-4316-B5DA-5CD5CF947ED4Q41195414-BE5B0FB7-46F2-4E29-8C95-2BEF61211C12Q41508524-064372BD-45EB-4093-9BBB-485EA91B3BD7Q41716096-082C84A3-1522-48EE-9265-0761E9129171Q41927898-BE68F15F-7B83-4E17-A7E2-061E3C6CBBB2Q45045855-72C9594F-E0D4-4880-8F31-E3C8093888ABQ45619589-0F508337-A729-4CEB-9ACE-9EB5FA10401FQ46133668-6409CCE2-0A8F-40F0-854E-7F322BB5191FQ47194979-B8A08936-B9BA-4E57-B722-044D42464973Q47282463-3DB9B25B-B391-4FAF-BC35-A2DF874EF2BAQ47778748-82B0052E-681B-4E39-B421-11128CD9A833Q48191794-EF63D9A5-C5BD-4687-A6A3-8ED33F88CDF1Q54377682-143FB2DC-DD3A-43F6-BA94-FDBA39AA7F66
P2860
Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice
description
2013 nî lūn-bûn
@nan
2013 թուականին հրատարակուած գիտական յօդուած
@hyw
2013 թվականին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@ast
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@en
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@nl
type
label
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@ast
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@en
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@nl
prefLabel
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@ast
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@en
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@nl
P2860
P50
P3181
P1433
P1476
Silencing mutant ataxin-3 resc ...... Joseph disease transgenic mice
@en
P2093
Isabel Nascimento-Ferreira
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0052396
P407
P577
2013-01-01T00:00:00Z