Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. - Wikidata - thesis-toulmin - TriplyDB

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

http://www.wikidata.org/entity/Q30481610

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Mouse models of polyglutamine diseases: review and data table. Part I Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.RNA interference mitigates motor and neuropathological deficits in a cerebellar mouse model of Machado-Joseph disease Longitudinal tracking of gait and balance impairments in cerebellar disease Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model.Toward understanding Machado-Joseph disease Fusion of Human Fetal Mesenchymal Stem Cells with "Degenerating" Cerebellar Neurons in Spinocerebellar Ataxia Type 1 Model Mice.Consensus Paper: Cerebellar Development.Caloric restriction blocks neuropathology and motor deficits in Machado-Joseph disease mouse models through SIRT1 pathway.Toward RNAi therapy for the polyglutamine disease Machado-Joseph disease Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias.Basic research on cerebellar gene therapy using lentiviral vectors.Mouse models of spinocerebellar ataxia type 3 (Machado-Joseph disease).Mesenchymal stem cells as a potential therapeutic tool for spinocerebellar ataxia.Induced pluripotent stem cell technology for modelling and therapy of cerebellar ataxia.CRMP5-associated GTPase (CRAG) protein protects neuronal cells against cytotoxicity of expanded polyglutamine protein partially via c-Fos-dependent activator protein-1 activation.Unravelling Endogenous MicroRNA System Dysfunction as a New Pathophysiological Mechanism in Machado-Joseph Disease.Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates.Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.Transduction Profile of the Marmoset Central Nervous System Using Adeno-Associated Virus Serotype 9 Vectors.Re-establishing ataxin-2 downregulates translation of mutant ataxin-3 and alleviates Machado-Joseph disease.Stem cell models of polyglutamine diseases and their use in cell-based therapies.One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.Mutant ataxin-3 with an abnormally expanded polyglutamine chain disrupts dendritic development and metabotropic glutamate receptor signaling in mouse cerebellar Purkinje cells.Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells.Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.Caffeine alleviates progressive motor deficits in a transgenic mouse model of spinocerebellar ataxia.Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado-Joseph disease.The natural history of cerebellar degeneration of Niemann-Pick C mice monitored in vitro.Elavl3 is essential for the maintenance of Purkinje neuron axons.Beclin 1 mitigates motor and neuropathological deficits in genetic mouse models of Machado-Joseph disease.Repeated Mesenchymal Stromal Cell Treatment Sustainably Alleviates Machado-Joseph Disease

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Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.

http://www.wikidata.org/entity/Q30481610

description

2008 nî lūn-bûn

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年学术文章

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Lentivector-mediated rescue fr ...... del of spinocerebellar ataxia.

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Lentivector-mediated rescue fr ...... del of spinocerebellar ataxia.

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Lentivector-mediated rescue fr ...... del of spinocerebellar ataxia.

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Lentivector-mediated rescue fr ...... odel of spinocerebellar ataxia

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Akira Iizuka

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Chiho Koyama

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Haruyasu Yamaguchi

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Kazuhiro Mitsumura

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Kiyohiko Takayama

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Miho Oue

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Shigeru Yanagi

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Takashi Torashima

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P2860

A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence

A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons.

Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes.

Patterned Purkinje cell death in the cerebellum.

A mutant ataxin-3 putative-cleavage fragment in brains of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.

Cell cycle arrest enhances the in vitro cellular toxicity of the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch.

The CAG/polyglutamine tract diseases: gene products and molecular pathogenesis.

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393-399

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10.1038/EMBOR.2008.31

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9

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18344973

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