Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
about
Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of DynamicsFine-tuning multiprotein complexes using small moleculesFeatures of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinityNitric oxide synthases: structure, function and inhibitionDiscovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivoSmall-molecule inhibitors of protein-protein interactions: progressing towards the dreamAdvantages and application of label-free detection assays in drug screening.Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.Intracellular formation of "undisruptable" dimers of inducible nitric oxide synthase.An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome dataRegulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors.A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensorsTargeting protein-protein interactions for therapeutic intervention: a challenge for the future.Visualizing inducible nitric-oxide synthase in living cells with a heme-binding fluorescent inhibitor.Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain.Dimeric switch of Hakai-truncated monomers during substrate recognition: insights from solution studies and NMR structureNitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis.Novel strategies for targeting the dimerization interface of HIV protease with cross-linked interfacial peptides.Novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthaseTampering with cell division by using small-molecule inhibitors of CDK-CKS protein interactions.Protein-protein interactions as drug targets.Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal.Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles.Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma.In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.Module assembly for designing multivalent mid-sized inhibitors of protein-protein interactions.Oncogenic protein interfaces: small molecules, big challenges.Computer applications for prediction of protein-protein interactions and rational drug design.Nitric oxide synthase and structure-based inhibitor design.Anti-Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis.Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.Cobalamin in inflammation III - glutathionylcobalamin and methylcobalamin/adenosylcobalamin coenzymes: the sword in the stone? How cobalamin may directly regulate the nitric oxide synthases.A combination of 3D-QSAR, molecular docking and molecular dynamics simulation studies of benzimidazole-quinolinone derivatives as iNOS inhibitors.Disrupting the Constitutive, Homodimeric Protein-Protein Interface in CK2β Using a Biophysical Fragment-Based Approach.Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle.Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III.Ethanol-induced modulation of inducible nitric-oxide synthase activity in human A172 astrocytoma cells.Differential susceptibility of Plasmodium falciparum versus yeast and mammalian enolases to dissociation into active monomers.Inducible nitric oxide synthase dimerization inhibitor prevents cardiovascular and renal morbidity in sheep with combined burn and smoke inhalation injury.The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury.
P2860
Q26785992-8A033BF4-06D8-4AB5-A1B4-BFC3DD8676D7Q26822675-C555DCFB-C8E7-40F5-BB7C-F1DC5CE25058Q26996645-55D523B7-A84A-42B8-AC7C-56CAE98A3DB4Q28207668-57442197-219A-4664-9CAF-14C0D5294114Q28541741-8E1E7C62-BA87-4B4E-8504-C62B97BAFCD4Q29617758-C6A44C2D-C789-43E6-9C91-A0B05DEFA724Q30597676-7B2C6056-32FE-4413-9293-074BDBD4DFA2Q30878526-8205CAB7-39AA-412A-A903-A4B1F9A81839Q31024396-EF9DE721-F0CF-4EB3-96C0-698546C99ADBQ31122058-AD72B383-1B4A-4DC7-89DA-66D49681E86AQ33582759-C3443B7F-51C9-4289-A686-82A876602CFAQ33584683-A83CF090-7EBC-4053-A766-D61D203CC690Q33852396-B4C64D0B-6028-447D-9FD6-E0EB8527DBB5Q33900440-723B75C8-829F-4B5E-8BA2-5BBA48BED1FAQ34067176-6A953DD9-E44B-4223-908B-7D83327F5565Q34170693-78D4F702-BEA3-4BDF-B639-AF77F94A73A1Q34344162-BC474B23-F197-4C36-8435-35D2C6975D5FQ34906959-C19BCC55-ED1A-4E79-B500-471EDD5D0D7FQ35087382-B903F1DC-ECA8-4DCB-885E-F27E19BF0469Q35548864-74053A82-FB27-42B3-9FC6-D575D30BBC3CQ35824701-EAA4A7DA-F5D3-44C3-B785-B780B41A8856Q36666934-C83FC46A-0EA2-4DDC-9C0E-987999B5498FQ37000579-AF61D558-0025-4791-9F19-9A7EB4A25A02Q37605833-93677CC7-55D6-4AC9-8151-AF6112006198Q37855883-FC234EB9-86E4-41C3-98F4-0C483F3D190DQ38168810-587F37AC-7A02-4B4B-AE72-A30E960868E2Q38195457-D942F05A-F863-417B-8332-9122FA9B27B9Q38364115-96D5BD03-0729-4062-8B41-AFDE7F3D2456Q39021613-F6D9A3DC-C785-4318-8F6A-A7D621D7E8B9Q39038155-01652A6E-B5B6-4581-926B-1867E24CDF0CQ41810165-01AD9495-D867-4BCC-906A-94D153327CA2Q41812699-22F55091-AA35-4264-AF4C-A53F3AB94838Q41836001-7AFC8B2E-2CE3-40E9-9592-2567253CDE1CQ42154255-EA1E9674-0B60-4337-94E1-210F12534144Q43759228-4BA52DD0-8FD3-41CC-A7CF-895E7A722CF6Q44016910-1BABB495-E73E-4485-9FA5-0E8D6BBEE2D7Q44156421-35D3179B-D2D3-4266-89C0-BFD7EE4B1D4BQ47828180-FCF7B998-3111-4E52-AC86-BCAFCF7377A2Q48960506-EF751A76-BF6D-416B-A70B-4AA1572F5ACAQ51301590-D6DFD649-B433-4601-9DB4-F86C13137323
P2860
Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry
description
2000 nî lūn-bûn
@nan
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@ast
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@en
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@nl
type
label
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@ast
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@en
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@nl
prefLabel
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@ast
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@en
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@nl
P2093
P2860
P356
P1476
Allosteric inhibitors of induc ...... ed via combinatorial chemistry
@en
P2093
C B Glaser
G B Phillips
J F Parkinson
J J Baldwin
P2860
P304
P356
10.1073/PNAS.97.4.1506
P407
P577
2000-02-15T00:00:00Z