Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease
about
Computational design of a PDZ domain peptide inhibitor that rescues CFTR activityStructure-based methods for predicting target mutation-induced drug resistance and rational drug design to overcome the problemHIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant VariantsPredicting resistance mutations using protein design algorithmsDrug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor bindingStructural, kinetic, and thermodynamic studies of specificity designed HIV-1 proteaseIdentification of structural mechanisms of HIV-1 protease specificity using computational peptide docking: implications for drug resistance.Understanding ligand-receptor non-covalent binding kinetics using molecular modeling.Computational design of affinity and specificity at protein-protein interfacesMolecular Basis for Drug Resistance in HIV-1 ProteaseValidating the vitality strategy for fighting drug resistance.Improving the description of salt bridge strength and geometry in a Generalized Born model.Charge Optimization Theory for Induced-Fit Ligands.Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided DesignComputer-aided design of functional protein interactions.The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design.The challenge of developing robust drugs to overcome resistance.Computational protein design with a generalized Born solvent model: application to Asparaginyl-tRNA synthetase.Multiple drugs and multiple targets: an analysis of the electrostatic determinants of binding between non-nucleoside HIV-1 reverse transcriptase inhibitors and variants of HIV-1 RT.A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 proteaseProtein:Ligand binding free energies: A stringent test for computational protein design
P2860
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P2860
Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 protease
description
2008 nî lūn-bûn
@nan
2008 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Computational design and exper ...... vated mutant of HIV-1 protease
@ast
Computational design and exper ...... vated mutant of HIV-1 protease
@en
Computational design and exper ...... vated mutant of HIV-1 protease
@nl
type
label
Computational design and exper ...... vated mutant of HIV-1 protease
@ast
Computational design and exper ...... vated mutant of HIV-1 protease
@en
Computational design and exper ...... vated mutant of HIV-1 protease
@nl
prefLabel
Computational design and exper ...... vated mutant of HIV-1 protease
@ast
Computational design and exper ...... vated mutant of HIV-1 protease
@en
Computational design and exper ...... vated mutant of HIV-1 protease
@nl
P2093
P2860
P356
P1433
P1476
Computational design and exper ...... vated mutant of HIV-1 protease
@en
P2093
Celia A Schiffer
Ellen A Nalivaika
Michael D Altman
Moses Prabu-Jeyabalan
P2860
P304
P356
10.1002/PROT.21514
P407
P50
P577
2008-02-01T00:00:00Z