Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates
about
Structural and kinetic analysis of drug resistant mutants of HIV-1 proteaseStructural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexesCombining mutations in HIV-1 protease to understand mechanisms of resistanceViability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapyComputational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 proteaseCaught in the Act: The 1.5 Å Resolution Crystal Structures of the HIV-1 Protease and the I54V Mutant Reveal a Tetrahedral Reaction Intermediate †Highly conserved glycine 86 and arginine 87 residues contribute differently to the structure and activity of the mature HIV-1 proteaseStructural, kinetic, and thermodynamic studies of specificity designed HIV-1 proteaseEffect of substrate residues on the P2' preference of retroviral proteinasesHelical structure determined by NMR of the HIV-1 (345-392)Gag sequence, surrounding p2: implications for particle assembly and RNA packagingMolecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.Mechanism of substrate recognition by drug-resistant human immunodeficiency virus type 1 protease variants revealed by a novel structural intermediateDesign, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.DOCK 6: Impact of new features and current docking performance.Structural basis for coevolution of a human immunodeficiency virus type 1 nucleocapsid-p1 cleavage site with a V82A drug-resistant mutation in viral protease.Narrow substrate specificity and sensitivity toward ligand-binding site mutations of human T-cell Leukemia virus type 1 protease.A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 proteaseSub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid
P2860
Q27619254-C41D2D19-572B-4C93-933A-A3F6F6E91835Q27631613-B69B2495-1C7E-4C90-BD31-E3ECFCBBC30AQ27638993-A1A6EDDB-C5A5-4F1A-9599-E38E6EBB8A8CQ27640250-5D20D7FC-990E-4D9C-A387-6A8160EA7310Q27647665-7FAF4DB5-5B74-4BAB-9C2C-83B53EF54452Q27649183-D1A5716F-5FB5-4610-B797-0B88373729B6Q27658105-EA5958B5-FA7F-4AB7-BC10-699BBE9D7C3AQ27678853-42AD9F5A-ADF9-44B2-88E0-74F8FF4FA313Q28372993-330325C7-1B97-40D1-9B5C-732206D96DDBQ30980940-962E6F8B-5F22-49F6-BCDF-9594356DBFA5Q34334101-17E4EEF5-34B9-4944-81B2-C51F347B5246Q34545639-ED76736B-09A2-495D-A299-2628E7B80B09Q34885997-6D98F9E1-B286-4B7F-82F4-83782A8D6E29Q35748554-65D7C8A8-CB97-4B09-A2AB-41A3370B3235Q37596952-1D46587D-767A-4D72-B454-4EE27C7BD411Q44854785-F688B4FA-3037-44D9-80F6-5CEE13745C9FQ56889055-0F73788A-88D5-479E-9804-419CF27E0F12Q57803375-F83A6941-2954-4722-9024-2E2F4ACBCFCC
P2860
Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates
description
1997 nî lūn-bûn
@nan
1997 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Crystallographic analysis of h ...... at P2' position of substrates
@ast
Crystallographic analysis of h ...... at P2' position of substrates
@en
Crystallographic analysis of h ...... at P2' position of substrates
@nl
type
label
Crystallographic analysis of h ...... at P2' position of substrates
@ast
Crystallographic analysis of h ...... at P2' position of substrates
@en
Crystallographic analysis of h ...... at P2' position of substrates
@nl
prefLabel
Crystallographic analysis of h ...... at P2' position of substrates
@ast
Crystallographic analysis of h ...... at P2' position of substrates
@en
Crystallographic analysis of h ...... at P2' position of substrates
@nl
P2093
P2860
P1433
P1476
Crystallographic analysis of h ...... at P2' position of substrates
@en
P2093
A R Kimmel
E M Wondrak
R W Harrison
P2860
P304
P356
10.1111/J.1432-1033.1997.00523.X
P407
P577
1997-10-15T00:00:00Z