Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ - Wikidata - thesis-toulmin - TriplyDB

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

http://www.wikidata.org/entity/Q27649166

about

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining A human XRCC4-XLF complex bridges DNA XRCC4's interaction with XLF is required for coding (but not signal) end joining XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4 Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2 Structures of SAS-6 suggest its organization in centrioles XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.The response to and repair of RAG-mediated DNA double-strand breaks Role of non-homologous end joining in V(D)J recombination Nonhomologous end joining: a good solution for bad ends DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF.Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.Brief report: a human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors.XLF regulates filament architecture of the XRCC4·ligase IV complex.Non-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex.Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair Cernunnos deficiency reduces thymocyte life span and alters the T cell repertoire in mice and humans.Lif1 SUMOylation and its role in non-homologous end-joining.Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo.DNA strand breaks, neurodegeneration and aging in the brain.E1B 55k-independent dissociation of the DNA ligase IV/XRCC4 complex by E4 34k during adenovirus infection Requirement for XLF/Cernunnos in alignment-based gap filling by DNA polymerases lambda and mu for nonhomologous end joining in human whole-cell extracts Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining.

P2860

Q22065419-9451677F-3E86-47A9-98D2-CE84C93F10DD Q24294110-18548DE6-3FC8-4093-8A70-88AD12779A6C Q24313240-4E243D4F-C466-4054-AAC5-6D756DCFD8DA Q24622950-7C1E5616-14D4-47EF-8FEA-C6B52928233B Q24630031-F784777F-6B10-44FC-82DF-6B512E36AA9B Q24630098-A50B239D-6365-4924-B77D-52AA53FCE338 Q24642915-2F28B24A-DE0B-44AC-A579-60F425523BFA Q24644339-54A663F1-60CB-466D-BD19-40DD779F842A Q24646190-607A4746-6812-4746-ADFF-C2C472B6449D Q24647310-91EFFC5D-93A2-470F-A1B8-8AB37D858C93 Q27666600-3382D8D8-3345-4F61-A2BA-5B680ECEF53B Q27670908-C11C3164-6CBF-4D79-B400-ED63C640B96D Q27674365-9D144B2B-748A-4073-A7D3-342E977493A6 Q27933248-F8778247-123F-4742-A513-0E5FE50D3069 Q28256889-C04C8C81-27B7-47E9-B27E-7D51620B1CCC Q28266265-9276F973-C04E-4B23-AC27-2349B9D001BF Q33625010-AFAC45DC-23C3-4421-A93D-24480438DC71 Q33865414-F3DEBE75-F922-4069-B7F8-8178F61256E5 Q34004894-1697DC28-32CE-47A0-9408-41444E1028B1 Q34074446-F649DD23-3707-491E-A14F-2DD0A1F748A9 Q34152519-BBFC45F8-7D67-47AA-BFAF-7120CA6E214D Q34329896-8ABCBBB9-BEF0-441C-8CF1-165FE3FEF72B Q34354862-1EDEB3F7-3098-4CF2-A04A-A00E87CD480D Q34433470-88AF52B9-DA14-48A0-9A8F-5D9892FB5495 Q34550224-F501FE33-CE27-4ED0-BB40-612C9875C3A7 Q34813549-E4D56B54-792E-4D67-A6A7-E47E1436527E Q35539378-34E1A54D-C15B-4D71-BA0D-083624EC92AD Q35661237-ABB28699-B53B-4314-A5E4-D85D6B1FD5CD Q35844884-B42E7C09-8CDC-44AA-A789-6A26DC21CFA0 Q35917467-EB1517D3-597C-47DF-8FAE-D8BFE1A64F1F Q36542548-8FFD377C-9C82-4176-A14D-62B4591284F5 Q36606978-975886F9-8F90-4FB5-B015-38F2C47D003B Q36878460-EBF4BC58-7DD0-4583-810F-8AB2F6F88DF0 Q36935474-568E2B1C-7403-4737-939C-D6E306C5E181 Q37099920-E2CA94FF-913E-46EE-B7B8-040FC34939F9 Q37154126-14351BEF-CA22-4B86-8ADB-DED637046D92 Q37210181-26192F53-215D-4DCA-A7DA-9396F980EA85 Q37259065-84789E80-E12F-4EA8-A611-A93223264C17 Q37289660-1B547B9A-B5B6-4D0A-A9A2-F50C39946976 Q37365625-48BFBEF8-3E12-41AC-BF7C-F2DDD01143A2

P2860

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

http://www.wikidata.org/entity/Q27649166

description

2008 nî lūn-bûn

@nan

2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2008年の論文

@ja

2008年論文

@yue

2008年論文

@zh-hant

2008年論文

@zh-hk

2008年論文

@zh-mo

2008年論文

@zh-tw

2008年论文

@wuu

name

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@ast

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@en

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@nl

type

label

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@ast

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@en

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@nl

prefLabel

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@ast

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@en

Crystal structure of human XLF ...... CC4 with implications for NHEJ

@nl

P1433

Q27649166-F4230901-B846-457F-80D4-4644B551D4E8

P1476

Q27649166-74CD3121-6C44-4BAC-96B0-F842C0AA6426

P2093

Q27649166-124FA628-F391-4DD7-9E65-E4BE20B84781

Q27649166-463F1755-BA05-46A8-8E27-D7CBDD5673AE

Q27649166-F9491927-C0A4-40B4-9059-901FBC260C79

P2860

Q27649166-08DDECC1-E79A-4CBC-BC3D-2BAA4F83B981

Q27649166-1C680EBB-4260-443F-AB1E-3C29054C5BDE

Q27649166-222A16D1-03AC-4DCE-BA11-1824C73A8944

Q27649166-288AE21C-1BDF-4459-AFAD-CB3FD5B5FA77

Q27649166-2C13F6BC-2D5B-4F29-B3FC-789AF058A4D0

Q27649166-2E4E35D2-E6A8-486B-900E-469E7C17E713

Q27649166-355AFD23-B719-4FD1-8B79-45932C752251

Q27649166-38FAF334-102F-41FF-9118-17E4AA42B8D6

Q27649166-397C1792-20A6-4EDD-8820-0F6F4178E20E

Q27649166-45D286F9-3C8B-428A-9234-569E8ACBC16E

P304

Q27649166-C2D99B92-AA3F-4D9B-A1E6-8B6B9A79687C

P31

Q27649166-FC81D2E1-2019-4F79-98C9-207227815208

P3181

Q27649166-4FEC952E-1D61-497A-9772-A97D40B36FCC

P356

Q27649166-802A846A-24E9-44A8-A96B-012EE2F66A05

P407

Q27649166-B5338742-B23D-4574-BE33-45E034BB6B31

P433

Q27649166-C9D842C9-3142-4062-8CAD-84EC7CF52AE5

P478

Q27649166-880AEB44-A471-4E21-9F44-202649BBA9D5

P50

Q27649166-0E3103F2-5AFF-4A00-BB08-03E5D5B4CE6D

Q27649166-58517874-F2CB-4E68-BD74-27110C15EAED

Q27649166-8B61A162-E4EC-410A-8562-9CB706705E38

Q27649166-C57E925D-B437-4469-913D-232E2EF764CD

Q27649166-F4C468E4-4FCC-4677-9A97-6BAFFDB47900

P577

Q27649166-D5EE1B41-4FD2-47A5-86CA-3F92A850FB26

P5875

Q27649166-4622E34D-815C-47A8-B18B-DA207610D850

P698

Q27649166-C56254E0-F6AE-4581-8D7B-57DB9E357CDF

P921

Q27649166-345D0933-3581-4433-A601-955D01E9F6EC

P932

Q27649166-AA49D0FF-DEF9-49BA-8E70-6A427118497D

P3181

P356

SJ.EMBOJ.7601942

P1433

The EMBO Journal

P1476

Crystal structure of human XLF ...... C4 with implications for NHEJ.

@en

P2093

Bancinyane L Sibanda

http://www.w3.org/2001/XMLSchema#string

Peter Ahnesorg

http://www.w3.org/2001/XMLSchema#string

Yi Li

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of an Xrcc4-DNA ligase IV complex

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

Synapsis of DNA ends by DNA-dependent protein kinase

Nonhomologous end joining and V(D)J recombination require an additional factor

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

ExPASy: The proteomics server for in-depth protein knowledge and analysis

P304

290-300

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3748379

http://www.w3.org/2001/XMLSchema#string

P356

10.1038/SJ.EMBOJ.7601942

http://www.w3.org/2001/XMLSchema#string

P407

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

27

http://www.w3.org/2001/XMLSchema#string

P50

Stephen P Jackson

Victor M Bolanos-Garcia

Dimitri Y Chirgadze

P577

2008-01-09T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5802349

http://www.w3.org/2001/XMLSchema#string

P698

18046455

http://www.w3.org/2001/XMLSchema#string

P921

crystal structure

P932

2104711

http://www.w3.org/2001/XMLSchema#string